杀虫剂暴露对健康影响方向的博士研究员

This PhD position will advance our knowledge regarding environmental pesticide exposure and cognition in children. The project does two things: It analyses biomonitoring data of pesticide exposure with tests of brain function of the children. It also examines the full Dutch population to understand risks of pesticide exposure to cognitive development and school functioning in children. Childhood cognitive development shapes health and success later in life, understanding how environmental risk factors alter children's brain function, learning and behaviour matters well beyond childhood.

Your job Pesticides are applied to crops to protect them from weeds, insects, fungi and other pests that reduce yield. Because they're used widely around the world, people are exposed to them chronically. This has raised concerns about health effects, especially for people who live close to treated fields.

In this project, we collect data from children taking part in the national OBO2 study. We use biomonitoring to measure their current pesticide exposure and link it to their brain function, which we assess with a test battery. We also apply geospatial exposure estimates developed within the OBO2 consortium to the school results of all children in the Netherlands. In your PhD project, you'll analyse both data sources to investigate possible health effects of pesticide exposure. Two methodological challenges run through both studies. Children are exposed to many pesticides at once, so you'll use mixture modelling to estimate their combined effects rather than looking at one compound at a time. And because the data follow children and exposures over several years, you'll apply longitudinal methods to study how exposure relates to cognition and school performance over time. We're looking for a candidate with a strong background in epidemiology and quantitative methods, solid programming experience in R.

The project is part of a national research program on pesticides and health. For the analyses of child cognition, you’ll be part of a team of researchers, including other (PhD) students and external collaborators involved in the OBO-2 project ( https://www.bestrijdingsmiddelen-omwonenden.nl/over-onderzoeken ). You'll work within the dynamic One Health Chemical (OHC) group, which is performing interdisciplinary research to uncover environmental health determinants.