细胞神经科学方向博士研究员
PhD-student in cellular neuroscience
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在从分子层面理解突触如何以时空精度形成，研究细胞表面蛋白如何结合mRNA和翻译机器，并探讨mRNA捕获与翻译的调控机制及其对突触形成和功能的影响。工作将使用啮齿类动物培养神经元和人iPSC衍生神经元，运用遗传学、活细胞成像和超分辨率成像等工具开展研究。
- 申请条件
- 原文未说明具体学位或专业背景要求，主要职责包括在培养的啮齿类和人iPSC衍生神经元中进行mRNA、翻译及受体的成像，开发新型遗传和成像工具研究mRNA和核糖体动态，开展功能测定，在同行评审期刊发表文章，承担约10%时间的教学活动（如指导本硕学生实习），以及向国际研究社群展示研究成果。
- 待遇
- 月薪为 EUR 3204 至 EUR 4051。
- 申请方式
- 原文未说明具体的申请方式、截止日期及提交地址。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/Amsterdam） 剩 18 天
- 学科
- 神经科学
- 合同类型
- 雇佣合同
- 原文薪资
- EUR 3,204–4,051 / 月（税前）
- 税后月薪（估）
- ¥19,000–¥24,000；房租后 ¥11,100–¥16,100
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 25%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- AcademicTransfer（荷兰学术招聘） · 最近核对 2026-10-19
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
As a PhD candidate your main tasks and responsibilities are:
- 工作语言为英语（通过国际研究网络和发表要求体现，无本地语言要求）
You will be part of international research networks and exploit a variety of techniques and analysis tools available.
原文
Project description: Our ability to walk, talk and form memories requires that neurons in our brain form, maintain and adapt billions of synaptic connections to establish functional neuronal circuits. It is unclear how neurons supply the protein complexes required to build these synapses in the right time and place. This project aims to provide a molecular understanding of how synapses are formed with spatiotemporal precision.
While protein synthesis was long considered to occur exclusively in neuronal cell bodies, recent research from our group and others has revealed that mRNA localization allows neurons to rapidly synthesize new proteins at defined subcellular locations. Indeed, hundreds of mRNAs are found at synapses. However, we do not know how these mRNAs are precisely captured and translated at specific sites, and how this contributes to the formation of functional synapses.
Synapse formation is initiated by the interaction between cell surface proteins on both sides of a synapse. My lab has recently uncovered that specific cell surface proteins bind mRNAs and translational machinery in neurons. This provides a powerful way for neurons to regulate the localization and selective translation of mRNAs. The aim of this NWO-funded project is to investigate this exciting new mechanism and examine how mRNA capture and translated are regulated and contribution to synapse formation and function.
In this project, you will use and develop genetic and imaging tools established in the Koppers lab together with live-cell imaging and functional assays to: • Unravel the molecular mechanisms of synaptic mRNA capture and translation during synapse formation • Control synaptic mRNA localization to modulate synapse formation.
The work will be carried out in rodent neurons in culture and human iPSC-derived neurons.
You will be part of international research networks and exploit a variety of techniques and analysis tools available. All the core methodology, cell models, equipment, analysis software and viral vectors are available from the start of the project. You will be trained on site and in specialized courses on campus.
Your duties: As a PhD candidate your main tasks and responsibilities are: • Imaging of mRNA, translation and receptors at synaptic sites in cultured rodent and human iPSC-derived neurons • Investigate and control the dynamics mRNAs and ribosomes by developing novel genetic and imaging tools with live-cell and super-resolution imaging • Performing functional assays to study synapse formation and function • Publishing analyses in peer-reviewed journals and provide progress reports to funding sources • Contributing to teaching activities (~10% of your time), including supervision of BSc and/or MSc students during internships • Presenting your work to the international research community