多突触可塑性与树突方向博士研究员
PhD Position: Multisynaptic Plasticity in Dendrites
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目结合单细胞电生理学、先进显微镜技术和新型生物传感器，研究脑片中海马CA1神经元树突内多突触可塑性背后的分子途径。研究目标包括确定内质网钙释放如何贡献于树突钙信号、探究PKA和PCOS活动如何与钙信号相互作用、评估这些相互作用是否能解释树突棘生长的两种模式，以及检查逆行信使等分子信号分子在何时何地产生。
- 申请条件
- 申请者需具备神经科学相关领域的硕士学位，是一名充满热情的青年科学家。
- 待遇
- 每月薪资在 EUR 3204 至 4051 之间，教学负荷最高可占工作时间的10%。
- 申请方式
- 原文未说明具体的申请方式、截止日期或提交地址。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/Amsterdam） 剩 17 天
- 学科
- 神经科学
- 合同类型
- 雇佣合同
- 原文薪资
- EUR 3,204–4,051 / 月（税前）
- 税后月薪（估）
- ¥19,000–¥24,000；房租后 ¥11,100–¥16,100
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 25%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- AcademicTransfer（荷兰学术招聘） · 最近核对 2026-10-21
- 详情核验
判定依据（原文摘录）
- 这是一个博士培养机会
Then you have a part to play as a PhD candidate in our research team.
- 要求硕士学位而非学士
Are you an enthusiastic young scientist with a Master's degree in a neuroscience-related field?
原文
Are you an enthusiastic young scientist with a Master's degree in a neuroscience-related field? And would you like to figure out how plasticity at multiple synapses is coordinated within dendrites? Then you have a part to play as a PhD candidate in our research team. Put your ideas to the test at our green campus and push your boundaries in an internationally friendly environment.
Synaptic plasticity is considered to be the foundation of brain adaptation and learning. Multiple signalling pathways have been identified that are underlying synaptic plasticity of single synapses, depending on induction protocol and cell type. However, linking these molecular pathways to behavioural adaptation and learning turned out to be difficult. Under physiological conditions in vivo, multiple synapses will be activated simultaneously and plasticity pathways will inherently interfere.
In this PhD project, we will use a combination of single cell electrophysiology, advanced microscopy techniques and novel biosensors to examine molecular pathways underlying multisynaptic plasticity in dendrites of hippocampal CA1 neurons in brain slices.
Research in the Wierenga lab focuses on the formation and plasticity of inhibitory synapses and the interactions between inhibitory and excitatory synapses within dendrites. In this project, you will use two-photon glutamate uncaging in hippocampal slices to induce synaptic plasticity at multiple spines and you will exploit novel biosensors to study interactions between molecular pathways within the dendrite. Furthermore, you will explore how these interactions are affected by neuromodulators. Pilot experiments with four spine stimulation have shown that large calcium signals emerge within the dendritic shaft that continue even after the stimulation has ended, and that there are at least two modes of spine growth that seem to be regulated independently.
The research has the following objectives: • To determine how calcium release from internal stores contributes to dendritic calcium signals. • To investigate how PKA and PKC activity interacts with calcium signals. • To assess if these interactions can explain the two modes of spine growth. • To examine when and where molecular signalling molecules (aka retrograde messengers) are produced.
Your teaching load may be up to 10% of your working time.
Would you like to learn more about what it’s like to pursue a PhD at Radboud University? Visit the page about working as a PhD candidate .