AstraZeneca肿瘤学下一代靶向蛋白质降解（TPD）非临床博士研究员（利用不依赖泛素的途径）
AstraZeneca Non-Clinical PhD Studentship in Next-generation TPD for oncology: Harnessing ubiquitin-independent pathways
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在通过利用Midnolin（一种能够将底物直接递送至蛋白酶体的蛋白质）进行不依赖泛素的降解，建立一个新颖的靶向蛋白质降解（TPD）平台。研究计划包括探索Midnolin生物学以了解其在细胞时空中的内源性调控，以及开发新工具将Midnolin活性引导至与治疗结果相关的理想肿瘤靶点。
- 申请条件
- 申请人应在相关学科获得或即将获得英国大学的一等或高2:1学士学位，或海外大学同等标准的学位，并对细胞生物学、生物化学及TPD方法具有强烈兴趣与良好知识或经验。
- 待遇
- 资助期限为4年，涵盖学生的生活津贴（stipend）以及Home标准的学费。该奖学金也对符合英国居留要求（按Home费率）或能通过奖学金/资助计划自行承担国际生学费差额的海外学生开放。
- 申请方式
- 申请截止日期为2026年11月16日星期一。申请应通过剑桥大学申请门户网站（University Application portal）提交，选择药理学博士（PhD in Pharmacology）课程并将本奖学金标题作为拟定项目标题，申请时请注明参考编号PL51373。
- 材料清单
- 一页A4纸的动机信（代替研究计划书上传，包含申请动机、相关技能、期望实现的成果及长期职业愿景）
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 33 天
- 学科
- 药理、毒理与药剂学
- 合同类型
- 奖学金
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Dr Catherine Lindon, Dr Gustavo Gutierrez, Professor Laura Itzhaki, Dr Sharan Bagal, Dr David McGarry
- 来源
- University of Cambridge 博士奖学金与 Studentships · 最近核对 2026-10-14
- 详情核验
判定依据（原文摘录）
- 允许学士学位申请
Applicants should have or shortly expect to obtain a first or high 2:1 bachelor's degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject.
原文
The Department of Pharmacology at the University of Cambridge, in partnership with AstraZeneca, is offering a funded PhD studentship to study proteasome-targeting tools and use them to design novel approaches for Targeted Protein Degradation (TPD). We are seeking a motivated and curiosity-driven student with a strong interest in cell biology and biochemistry, as well as an enthusiasm for TPD approaches.
The successful candidate will join the lab of Dr Catherine Lindon in the Department of Pharmacology, with a supervisory team that includes Dr Gustavo Gutierrez (Discovery Sciences, AstraZeneca), Professor Laura Itzhaki (Department of Pharmacology), Dr Sharan Bagal (Oncology Chemistry, AstraZeneca) and Dr David McGarry (Oncology Bioscience, AstraZeneca).
Project Aims:
The project aims to establish a novel TPD platform by co-opting Midnolin, a protein capable of delivering substrates directly to the proteasome, for ubiquitin-independent degradation. The research programme will include an exploration of Midnolin biology, to understand its endogenous regulation across cellular time and space, and the development of novel tools to direct Midnolin activity towards desirable targets linked to therapeutic outcomes. This part of the project will include a campaign to discover binders that can harness the cell's endogenous Midnolin pool, and engineering of custom exogenous Midnolin-based degrader tools, for directed degradation of oncology targets.
We are seeking a highly motivated individual able to work independently, and with good knowledge and/or experience in both biochemistry and cell biology. Applicants should have or shortly expect to obtain a first or high 2:1 bachelor's degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject.
Funding:
The funding for this post is available for 4 years. Funding will cover the student's stipend and tuition fees at the Home rate. This studentship is also open to overseas students who meet the UK residency requirements (home fees) or who can cover the extra costs associated with international student fees through scholarships or funding schemes. Students may not supplement fees via self-funding.
How to Apply:
The deadline for applications is Monday 16th November 2026. Applications should be made via the University Application portal. When asked to select a course, please apply for the PhD in Pharmacology. You should then put the title of this studentship as your proposed project title.
You are not required to write your own research proposal. When asked for a research proposal in the applicant portal, instead please upload one side of A4 with your motivation for applying for the studentship, your relevant skills, what you hope to achieve if appointed, and long-term career aspirations.
Informal enquiries about the project are welcome and should be directed to Dr Catherine Lindon: acl34@cam.ac.uk
For application process queries, please contact the Postgraduate Admissions Team https://www.postgraduate.study.cam.ac.uk/contact-us
Please quote reference PL51373 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.