恶性生殖细胞肿瘤中失调的microRNA介导的细胞途径的功能效应研究博士研究员
PhD Studentship (Fixed Term)
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目将通过体外工程化诱导型恶性生殖细胞肿瘤（GCT）细胞系，进一步研究失调的microRNA介导的细胞途径的功能效应，并探讨miRNA补充/靶向方法与顺铂及新型药物的联合治疗效果，为体内研究奠定基础。
- 申请条件
- 申请人应持有（或预计获得）相关专业本科荣誉学位或硕士学位的英国二等一级（2.1）或同等水平以上学历。职位仅对符合英国本地学费（Home fees）资格的学生开放，且必须在面试时满足学校的英语语言要求。
- 待遇
- 提供为期4年（从2027年10月起）的全额资助，涵盖按当前研究委员会标准的学生生活津贴以及英国本地大学学费。
- 申请方式
- 所有申请均须通过大学申请者门户网站在线提交，申请病理学博士项目（BLPA22），并在申请及任何通信中注明参考编号PK51398。截止日期为2026年12月2日。
- 材料清单
- 2封学术推荐信
- 说明申请该领域博士动机、阐述研究兴趣与背景以及说明能为该岗位带来何种品质和经验的陈述
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 49 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 奖学金
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Matthew Murray
- 来源
- University of Cambridge 博士奖学金与 Studentships · 最近核对 2026-10-14
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22).
- 仅限英国本地学费资格学生
The studentships are available to students who qualify for UK HOME FEES ONLY.
- 学士学位或硕士学位均可申请
Applicants should hold (or expect to obtain) the equivalent of a UK upper 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject.
原文
Project title: Exploring functional effects of dysregulated microRNA-mediated cellular pathways in malignant germ cell tumours ¿ Dr Matthew Murray.
Malignant germ cell tumours (GCTs) are characterised by microRNA (miRNA) dysregulation. Our studies to date have identified key tumour-suppressor and oncogenic candidate miRNAs warranting further study. We have already targeted/manipulated over-expressed miR-371~373 and miR-302/367 miRNAs and replenished downregulated miRNAs (let-7 and miR-100-5p/125b-5p) in malignant GCT cell lines with phenotypic and genotypic effects. This project will extend those observations in engineered inducible malignant GCT cell lines in vitro which can, e.g., express miR-100-5p/miR-125b-5p upon doxycycline treatment. Combination treatment using miRNA replenishment/targeting approaches with cisplatin will also be investigated, and novel agents targeting identified affected cellular pathways, prior to in vivo studies.
The Department of Pathology has an excellent reputation in pure biological and biomedical research and is offering fully funded* studentships from October 2027 to work with one of the Research Group Leaders in this large and vibrant Department.
All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22). A completed application must be submitted by the closing date below. An application is only complete when all supporting documents, including the 2 academic references, are submitted.
It is the applicant's responsibility to ensure their referees submit their references before the closing date of the studentship.
The studentships are available to students who qualify for UK HOME FEES ONLY.
Please check for eligibility details using this website: https://www.postgraduate.study.cam.ac.uk/finance/fees/what-my-fee-status
Funding will cover the student's stipend at the current Research Council rate and Home University Fees. The studentship will be funded for 4 years from October 2027.
Applicants should hold (or expect to obtain) the equivalent of a UK upper 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the language requirements for admission. (http://www.graduate.study.cam.ac.uk/courses/directory/blpapdpth/requirements)
Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.
Applications from ineligible candidates will not be considered.
Further information about the course can be found here.
Closing date: 2nd December 2026.
Please quote reference PK51398 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.