德国博士后：解析 BAF 相关的 ARID 蛋白与结肠癌的关系

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PhD position: Deciphering the disorder-mediated interactome of the BAF-associated ARID proteins with implications in colorectal cancer (m/f/d) Full PhD Working Language English

Location Mainz

Application Deadline 15. Oct 2026

Starting Date 01. Feb 2027

• Overview • Description • Required Documents • Application

Overview Open Positions 1

Time Span 01. Feb 2027 for 3 years

Application Deadline 15. Oct 2026

Financing yes

Type of Position Full PhD

Working Language English

Required Degree Master

Areas of study Biology, Molecular Biology

Description Description Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented scientists the chance to work on cutting edge research projects . As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory. Activities and responsibilities The research group of Katja Luck offers the following PhD project: Transcription, replication and DNA repair represent key processes that act on DNA to ensure cell survival. As DNA is packaged into chromatin, chromatin remodeling, for example by BAF complexes, is required to coordinate and support genome maintenance processes. The BAF complexes exist in three different subtypes, each composed of multiple subunits. In previous work by us in collaboration with the Schick lab (IMB), we found that loss of either of the three BAF subtype-determining ARID subunits results in distinct vulnerabilities and resistances upon treatment with genotoxic or cell cycle-inhibiting agents. Since mutation of the ARID subunits is frequently associated with cancer, we believe that these phenotypes are relevant to dissect molecular and cellular functions of the ARIDs and understand mechanisms that drive disease upon ARID perturbation. The challenge is that the ARID subunits are enormous proteins with more than 1000 residues being intrinsically disordered. They are thus, difficult to study, and little is known about their regulatory functions. The Schick and Luck lab have developed jointly new computational and experimental techniques that enable the study of the ARID proteins in unprecedented ways.

PhD Project: Deciphering the disorder-mediated interactome of the BAF-associated ARID proteins with implications in colorectal cancer

In this primarily experimental project, the PhD candidate will apply novel NGS and structural proteomics techniques in combination with structure prediction tools such as AlphaFold and other in-house developed software, to discover direct interaction partners of the ARID proteins and dissect their interaction interfaces. We hypothesize that most regulatory and differential interaction partners between the ARID proteins that drive different phenotypes, are mediated by the disordered regions of the ARID proteins, which are poorly studied. In collaboration with the Schick lab, the PhD candidate will work with CRISPR-engineered cell lines to validate interaction interfaces and dissect the relevance of these novel interaction partners in mediating ARID subunit-specific functions in the context of DNA repair and cell cycle regulation. We are particularly interested in the relevance of these findings for colorectal cancer with possible further functional characterization in colon organoids. This project is embedded within the collaborative research consortium SFB1361 ( www.sfb1361.de , pending funding decision in November 2026).

If you are interested in this project, please select Luck (BAF) as your group preference in the IPP application platform. Qualification profile Are you an ambitious scientist looking to push the boundaries of research while interacting with colleagues from multiple disciplines and cultures? Then joining the IPP is your opportunity to give your scientific career a flying start! All you need is: • Master or equivalent • Interactive personality & good command of English • 2 letters of reference

We offer • Exciting, interdisciplinary projects in a lively international environment, with English as our working language • Advanced training in scientific techniques and professional skills • Access to our state-of-the-art Core Facilities and their technical expertise • Fully funded positions with financing until the completion of your thesis • A lively community ofmore than 200 PhD students from 44 different countries

For more details on the projects offered and how to apply via the online form using the apply button.

The deadline for applications is 15 October 2026. Interviews will take place at IMB in Mainz on 18+19 January 2027. Starting date: 1 February - 31 July 2027

Required Documents Required Documents • Motivation letter • CV • Certificates • Transcripts • References

Application Application

https://www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/projects-offered/katja-luck-baf-1

https://www.imb.de/phd Contact Institute of Molecular Biology gGmbH (IMB) International PhD Programme (IPP) Mainz Address Street Ackermannweg 4 Zipcode 55128 City Mainz

Contact details Web: https://www.imb.de/phd