基于AI的虚拟神经元开发以应对tau蛋白病的博士研究员

DeepLife is looking for a highly motivated PhD candidate to join TAu imMunE (TAME), a European Doctoral Network dedicated to tauopathies (https://cordis.europa.eu/project/id/101119596). TAME brings together academic and industry partners across Europe to develop methods to better diagnose and treat tauopathies, including Alzheimer’s disease and frontotemporal dementia. Tauopathies are characterized by abnormal tau protein buildup in the brain, leading to the formation of filaments, obstructing nerve synapses and impacting cell viability, ultimately leading to neurodegenerative disorders. This PhD position is at the intersection of AI and experimental biology (wet lab). Using experimental biological data from cell cultures and in vivo models, together with AI models developed by DeepLife , the candidate will build and refine virtual neurons affected by tau pathology in order to predict novel biomarkers and therapeutic strategies. The project will involve interaction between wet-lab experimentation and AI-based modelling, with experimental results used to inform and validate the Virtual Neuron models, and computational predictions supporting the design and interpretation of biological experiments. The successful candidate will be hired by DeepLife under a 36-month full-time PhD employment contract. The candidate will spend: • 24 months within DeepLife’s R&D team • 12 months at Université de Lille / Inserm / Institut Pasteur de Lille, within the Integrative Structural Biology / Alzheimer & Tauopathies – Lille Neuroscience & Cognition research environment.

The PhD will be jointly supervised by DeepLife and Université de Lille. The candidate will also interact regularly with the TAME consortium and benefit from its biological and experimental expertise.

Requirements / required education level / degree: Master Degree or equivalent

Requirements / required education level / discipline: Biological sciences

Requirements / skills: We are looking for a candidate able and motivated to work at the interface between experimental biology and computational approaches, with a Master's degree or equivalent in cellular biology or bioinformatics ; • Hands-on wet-lab experience is required ; • Knowledge of Python is highly valued ; • Basic knowledge of machine learning and experience with omics/single-cell data would be an advantage.

Requirements / required languages / language: ENGLISH

Requirements / required languages / language level: Excellent

Research experience / main research field: Computer science

Research experience / research sub field: Modelling tools

Research experience / years of research experience: None

Research experience / main research field: Biological sciences

Research experience / research sub field: Biological engineering

Research experience / years of research experience: None

Additional information / benefits: The PhD fellowship duration is 3 years and correspond to a work contract protected by employment laws of the hosting country that includes full social benefit and a mobility allowance. Family allowance is provided if applicable. Salary and additional benefits are according to EU-standards for Marie Curie fellows The fellows will be enrolled in doctoral schools associated to the host institution. Starting date is as soon as possible.

Additional information / eligibility criteria: Candidate eligibility: Eligible candidates have to be in the first four years of their research careers and in possession of a European Master’s degree or equivalent but not yet awarded with a doctoral degree The researchers must not have resided or carried out their main activity (work, studies, etc.) in the hosting country for more than 12 months in the 3 years immediately prior to the start of the contract date. We are committed to equal opportunity recruitments

Additional information / selection process: How to apply: Applications should be sent directly by email to guillaine.lauriol@deeplife.co . Application must include at the minimum a copy of the Master diploma, a curriculum vitae and contact(s) to request for external evaluation and could include any additional documents that might be judged useful (Toefl score, academic notes…) Short-listed candidates will be invited for an interview, by teleconference if more convenient. Candidates that are not selected will be informed by email with a brief description of the reason for rejection. Selection criteria: To assess whether the candidate can initiate a PhD programme are the following: 1. (25%) Merit and excellence criteria: academic track record will be one of the considered criteria (examination and dissertation marks, courses followed, internships, etc.) 2. (20%) Knowledge and experience in the field 3. (20%) Non-academic skills, such as communication skills and team work 4. (25%) English language proficiency and criteria like previous mobility, teaching experience, publication record, awards. 5. (10%) external expert assessments (reference letter(s)). Application eligibility: Eligible application is received before the deadline & it is complete & the candidate possesses a European Master degree or equivalent at the time of the deadline & the candidate has an excellent proficiency of the English language

Additional information / comment: About DeepLife DeepLife is a techbio company developing Digital Twins of human cells to accelerate drug discovery. By combining large-scale multi-omics data, artificial intelligence and systems biology, DeepLife models cellular mechanisms to identify the molecular drivers of disease and uncover new therapeutic targets. DeepLife offers an international and research-driven environment, bringing together expertise in computational biology, machine learning and drug discovery. About TAME TAu imMunE (TAME) is a European Doctoral Network dedicated to tauopathies, bringing together academic institutions, research organisations and private companies across Europe. The research and training programme aims to generate new knowledge and innovative approaches for the diagnosis and treatment of tau-related neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia.

Additional information / info website: https://cordis.europa.eu/project/id/101119596

Additional information / info website: https://tame-itn.eu

Work location / nr job positions: 1

Work location / job organisation institute: Deeplife

Work location / job country: France

Work location / job city: Paris

Work location / job postal code: 75013

Work location / job street: 8 Rue Jean Antoine de Baïf

Work location / nr job positions: 1

Work location / job organisation institute: CNRS-UMR9031 Integrative structural biology

Work location / job country: France

Work location / job city: Villeneuve d'Ascq

Work location / job postal code: 59658

Work location / job street: Avenue de Halley

Hiring contact / organisation institute: Deelife

Hiring contact / organisation institute type: Small Medium Enterprise, Start-up

Hiring contact / country: France

Hiring contact / city: Paris

Hiring contact / postal code: 75013

Hiring contact / street: 8 Rue Jean Antoine de Baïf

Hiring contact / e mail: guillaine.lauriol@deeplife.co

Hiring contact / website: https://www.deeplife.co/

Application / how to apply: e-mail

Application / application email: guillaine.lauriol@deeplife.co

EU funding / framework programme: Horizon Europe - MSCA

EU funding / cofund nr job position: 1

EU funding / sesam agreement number: 101119596

EU funding / job reference number: HORIZON-MSCA-2022-DN-01

Research field / main research field: Computer science

Research field / sub research field: Modelling tools

Research field / main research field: Biological sciences

Research field / sub research field: Biological engineering

Researcher profile: First Stage Researcher (R1)

Positions: PhD Positions

Contract: Temporary

Job status: Full-time

Application deadline (as exported; timezone unverified): 2026-10-30T11:00:00