多组学与AMD疾病模型方向博士职位

Defining the multiomics profile of complement-mediated AMD models The PhD position is part of the MSCA Doctoral Network PANDORA on discovering Pathomechanisms and Novel Drug Optimization for AMD (Age-Related Macular Degeneration). The generation of omic profiles of disease models is a valuable tool to identify pathological mechanisms and disease biomarkers. The PhD student will create transcriptomic and proteomic profiles of different retinal cells that are involved in AMD, carrying specific genetic variants of the complement system, either at baseline or after exposure to dynamic changes mimicking the life-long modifications occurring in AMD in real life, including exposure to complement system overactivation, excessive oxidative stress or drug treatment. The position will provide state-of-the art training in vision research using advanced induced pluripotent stem cell (iPSC)-derived models, biochemical and molecular methodologies, transcriptomics, proteomics and data analysis with bioinformatics tools to integrate findings into disease models. We are seeking a highly motivated and intellectually curious PhD student, ideally with strong background in bioinformatics. The candidate will investigate omics profiles of AMD disease models. AMD is the most common cause of blindness in the elderly population and its pathological mechanisms are complex and not fully understood. The project aims to dissect AMD profiles depending on genetic variants, stressors and drug response. The results will help to design diagnostic paradigms and therapeutic approaches. The PhD candidate will benefit from a network of European experts in different fields (gene therapy, pharmacology, bioinformatics, disease modeling, imaging) and will have the possibility to visit other labs in secondments (lab exchanges). The doctoral candidate will utilize cutting-edge techniques: • Omics (proteomics and transcriptomics) • Cell and tissue culture (stem cell – derived retinal models) • Molecular biology and biochemistry techniques (qPCR, immunohistochemistry, western blot) • Cell analyses (in vitro assays, metabolism measurements)

Recent open access research publications related to this position: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1527018/full https://link.springer.com/article/10.1007/s00018-021-03796-9 https://pubmed.ncbi.nlm.nih.gov/31350409/ https://www.nature.com/articles/ncomms11491

Requirements / required education level / degree: Master Degree or equivalent

Requirements / required education level / discipline: Biological sciences

Requirements / required education level / degree: Master Degree or equivalent

Requirements / required education level / discipline: Neurosciences

Requirements / required education level / degree: Master Degree or equivalent

Requirements / required education level / discipline: Medical sciences

Requirements / skills: • A Master’s degree in life sciences (biology, neurobiology, bioinformatics or closely related fields) • Good background in statistics, bioinformatics and/or omic analyses • Excellence in oral and written English, with good presentation skills • High motivation with interest in retinal degeneration and disease mechanisms • Work effectively both independently and as part of a team • Knowledge of cellular and molecular biology, eye biology and/or neuroscience • Strong interest in the analysis of multi-omics data, and translational biomedical research

Requirements / specific requirements: • Hands on knowledge in cell culture, molecular biology and biochemistry techniques • Background in complement system biology is a plus

Requirements / required languages / language: ENGLISH

Requirements / required languages / language level: Excellent

Research experience / main research field: Medical sciences

Research experience / research sub field: Health sciences

Research experience / years of research experience: None

Additional information / benefits: The EU provides 36 months support for each recruited researcher. We offer a highly competitive salary, with a gross salary in the range of 3.924 € (before taxes and employees' social security deductions). The Institute for Ophthalmic Research is a vibrant academic environment, hosting 13 research labs and 2 clinical research labs, and a core facility for Medical Proteomics. The institution is renowned as a leading centre for vision research. As an integral part of Tübingen’s biomedical and neuroscience campus, we offer a scientific environment that favors creativity for generating groundbreaking ideas, their transfer into reality and their translation into diagnostics and therapy to help those that suffer from vision impairment. The candidate will have the opportunity to interact with other labs and will get exposure to an array of techniques relevant to disease modeling and therapeutics. We offer modern, state-of the art laboratories, facilities, and equipment, as well as participation in training activities of the international and intersectorial PANDORA network. We also promote participation in national and international conferences.

Additional information / eligibility criteria: The applicant • shall not have resided or carried out his/her main activity (work, studies etc.) in Germany for more than 12 months in the 36 months immediately before the recruitment date (unless as part of a compulsory national service or a procedure for obtaining refugee status under the Geneva Convention). • shall not already be in possession of a doctoral degree (*). • can be of any nationality.

*:researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible

Additional information / selection process: Doctoral candidates will be selected based on scientific qualification and experience, research interest, additional knowledge/skills and their motivation to participate in an intersectoral research-training program.

Additional information / comment: Please send your CV, specifying the title of the position, a 1-page cover letter and the contact details of one or two academic referees to: Dr. Ellen Kilger ellen.kilger@uni-tuebingen.de If you have informal enquiries- please contact Dr. Angela Armento angela.armento@uni-tuebingen.de

Work location / nr job positions: 1

Work location / job organisation institute: Institute for Ophthalmic Research

Work location / job country: Germany

Work location / job city: Tuebingen

Work location / job postal code: 72076

Work location / job street: Elfried-Aulhorn-Str. 7

Hiring contact / organisation institute: Institute for Ophthalmic Research

Hiring contact / organisation institute type: Public Research Institution

Hiring contact / division faculty: Ophthalmology

Hiring contact / country: Germany

Hiring contact / city: Tübingen

Hiring contact / postal code: 72076

Hiring contact / street: Elfriede-Aulhorn Str. 7

Hiring contact / e mail: ellen.kilger@uni-tuebingen.de

Hiring contact / e mail: angela.armento@uni-tuebingen.de

Hiring contact / website: https://www.medizin.uni-tuebingen.de/de/das-klinikum/einrichtungen/institute/forschungsinstitut-augenheilkunde

Hiring contact / website: https://www.eye-tuebingen.de/

Hiring contact / phone: 004970712984947

Hiring contact / phone: 004970712984953

Application / how to apply: e-mail

Application / application email: ellen.kilger@uni-tuebingen.de

EU funding / framework programme: Horizon Europe - MSCA

EU funding / cofund nr job position: 1

EU funding / sesam agreement number: 101312030

Research field / main research field: Medical sciences

Research field / sub research field: Health sciences

Research field / main research field: Biological sciences

Research field / sub research field: Biology

Research field / main research field: Neurosciences

Research field / sub research field: Neurobiology

Researcher profile: First Stage Researcher (R1)

Positions: PhD Positions

Contract: Temporary

Job status: Full-time

Application deadline (as exported; timezone unverified): 2026-10-15T21:59:00