自噬与视网膜变性方向博士职位
PhD Position: Autophagy and Retinal Degeneration:
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
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- 研究内容
- 项目研究干细胞衍生的RPE和小鼠视网膜AMD模型中自噬与补体失调之间的联系，重点关注选择性自噬通路（如线粒体自噬和溶酶体自噬），以探究视网膜变性的疾病机制并寻找潜在治疗靶点。
- 申请条件
- 申请者须持有生物医学科学、分子生物学、生物技术、神经科学或相关学科的硕士学位，具备细胞生物学、自噬或神经退行性疾病等背景，且英语流利。
- 待遇
- 在弗里堡大学提供为期3年（可在HORIZON-MSCA-2025-DN-01框架下延长1年）的全薪博士职位，并提供定制化的职业发展计划和国际化科研环境。
- 申请方式
- 申请者需通过电子邮件将申请材料发送至指定邮箱（boyalabfr@gmail.com），截止日期为2026年11月1日。
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由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
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- 学科
- 神经科学
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- 来源
- EURAXESS（欧洲科研人才门户，MSCA 官方导出） · 最近核对 2026-10-09
- 详情核验
判定依据（原文摘录）
- is_phd
A fully funded PhD position at the University of Fribourg for 3 years
- english_ok
Excellent proficiency in English
- bachelor_ok
Master Degree or equivalent
官方导出原文
Research Project Impaired proteostasis is a hallmark of many neurodegenerative diseases. Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss and is strongly associated with retinal pigment epithelium (RPE) dysfunction, altered complement activity, and impaired cellular quality-control pathways. The project will investigate the link between autophagy and complement dysregulation in stem cell-derived RPE and murine retina models of AMD. It will focus on selective autophagy pathways, including mitophagy and lysophagy, in induced pluripotent stem cell (iPSC)-based models The successful candidate will employ advanced molecular, cellular, and imaging approaches to investigate disease mechanisms and identify potential therapeutic targets in retinal degeneration. The findings are expected to have broader implications for neurodegenerative diseases. . We Offer • A fully funded PhD position at the University of Fribourg for 3 years, with possibility of extending one more year in the frame of HORIZON-MSCA-2025-DN-01.Project: 101312030, PANDORA. • Eligibility under the ITN-MSCA mobility rule: applicants must not have resided or carried out their main activity in Switzerland for more than 12 months in the 36 months immediately preceding their recruitment date. • An international, collaborative, and stimulating research environment. • Training in cutting-edge molecular, cellular, imaging, stem cell-based approaches and in laboratory animal experimentation in accordance with applicable Swiss ethical, welfare, and regulatory requirements. • A tailored career development plan with opportunities for scientific collaborations, conference participation, and professional development. • The opportunity to contribute to research addressing fundamental mechanisms and potential therapeutic strategies in AMD.
Requirements / required education level / degree: Master Degree or equivalent
Requirements / required education level / discipline: Biological sciences
Requirements / skills: We are seeking a highly motivated, collaborative and enthusiastic candidate with: • A master's degree in biomedical sciences, molecular biology, biotechnology, neuroscience , or a related discipline. • A strong interest in cell biology, neuronal and glial biology, autophagy, retinal biology, and/or neurodegeneration . • Experience in cell culture . Previous experience with iPSC culture and differentiation is an advantage but not essential. • Experience with molecular biology, microscopy, or related experimental techniques is desirable. • Willingness to work with murine models and contribute to experiments involving laboratory animals. Previous experience with animal experimentation is an advantage, but not essential. • Excellent analytical, organizational, and communication skills. Excellent proficiency in English . • Ability to work both independently and collaboratively in an interdisciplinary research environment.
Requirements / required languages / language: ENGLISH
Requirements / required languages / language level: Excellent
Research experience / main research field: Biological sciences
Research experience / research sub field: Other
Research experience / years of research experience: None
Research experience / main research field: Neurosciences
Research experience / research sub field: Neurobiology
Research experience / years of research experience: None
Work location / nr job positions: 1
Work location / job organisation institute: University of Fribourg
Work location / job country: Switzerland
Work location / job state province: Fribourg
Work location / job city: Fribourg
Work location / job postal code: 1700
Hiring contact / organisation institute: University of Fribourg
Hiring contact / organisation institute type: Higher Education Institute
Hiring contact / division faculty: Neuroscience and Movement Science
Hiring contact / country: Switzerland
Hiring contact / city: Fribourg
Hiring contact / postal code: 1700
Hiring contact / street: PER 02 bu. 1.412 Ch. du Musée 14
Hiring contact / e mail: boyalabfr@gmail.com
Hiring contact / website: https://www.unifr.ch/med/en/research/group/boya/
Application / how to apply: e-mail
Application / application email: boyalabfr@gmail.com
EU funding / framework programme: Horizon Europe - MSCA
EU funding / cofund nr job position: 1
Research field / main research field: Neurosciences
Research field / sub research field: Neurobiology
Research field / main research field: Biological sciences
Research field / sub research field: Other
Researcher profile: First Stage Researcher (R1)
Positions: PhD Positions
Contract: Temporary
Job status: Full-time
Application deadline (as exported; timezone unverified): 2026-11-01T16:00:00