计算系统生物学/生物信息学方向博士研究员（PANDORA项目）
PhD in Computational Systems Biology / Bioinformatics (M/F)
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 创建受年龄相关性黄斑变性（AMD）影响的视网膜的多尺度预测数字孪生体（DC8），开发视网膜机制的大规模分子相互作用图谱，并将其转化为可执行的布尔模型及基于代理的多尺度模型（ABM）。
- 申请条件
- 持有生物信息学、计算或系统生物学、具有强定量焦点的生物学、计算机科学、应用数学或紧密相关领域的硕士学位或同等学历；具备编程经验（如 Python、R 等）以及网络生物学、数学建模和/或组学数据分析的扎实知识；英语口头和书面表达优秀，具备良好的演讲技能。
- 待遇
- 作为MSCA PANDORA博士网络的一部分，提供全职临时合同岗位。
- 申请方式
- 通过官方指定的招聘网站（https://emploi.cnrs.fr/Offres/Doctorant/UMR5077-MARPEL1-027/Default.aspx）进行申请，截止日期为2026-11-10。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- 参见原文（截止时间尚未核验）
- 学科
- 生命科学
- 合同类型
- 雇佣合同
- 本站收录
- 内容更新
- 导师
- Anna NIARAKIS
- 来源
- EURAXESS（欧洲科研人才门户，MSCA 官方导出） · 最近核对 2026-10-10
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
As part of the PANDORA project, a PhD position is available at the Centre for Integrative Biology (CBI) in Toulouse
- 工作语言为英语且英语要求明确
Excellent command of spoken and written English, as well as good presentation skills.
- 要求硕士学位而非学士学位
Master Degree or equivalent
官方导出原文
As part of the PANDORA project, a PhD position is available at the Centre for Integrative Biology (CBI) in Toulouse, a joint CNRS–University of Toulouse unit dedicated to integrative biology at various scales. The successful candidate will join the Systems Biology group and will be supervised by Professor Anna NIARAKIS.Job description : Creation of a multi-scale predictive digital twin of the retina affected by age-related macular degeneration (AMD) (DC8) This PhD position forms part of the MSCA PANDORA doctoral network, which investigates the pathological mechanisms and optimisation of new drugs for age-related macular degeneration (AMD). Computational modelling enables researchers to integrate several types of biological data into a single framework, to test perturbations in silico, and to predict pathological mechanisms and responses to treatments before testing them in the laboratory. The PhD student will develop large-scale molecular interaction maps of retinal mechanisms linked to AMD and the complement system. They will convert these maps into executable Boolean models using the 'map-to-model' framework developed at the CNRS/UPS and INRIA, and then adapt the models to the specific conditions of AMD using omics data generated within the consortium. The models will then be integrated into an agent-based multi-scale model (ABM) to create a digital twin of the retina affected by AMD, simulating intercellular communication and tissue homeostasis.The digital twin will simulate the system disturbances studied experimentally at the network level: environmental stress conditions, different compositions of the extracellular matrix, gene inactivations and gain-of-function variants. The in silico predictions will be compared with in vitro data provided by the PANDORA project partners. Finally, the model will be used as part of a therapeutic reorientation strategy aimed at identifying and prioritising new therapeutic targets for AMD, which will then be passed on to the consortium for experimental validation.The host laboratory has recently developed a technology enabling Boolean models to be scaled up to a maximum of 1,000 biomolecules and ABM models to thousands of agents. The PhD student will build on these advances to create state-of-the-art, large-scale predictive models of AMD. We are looking for a highly motivated PhD student with a keen intellectual curiosity, possessing a solid background in computational or systems biology, bioinformatics or a related quantitative field.AMD is the most common cause of blindness in older people.Its pathological mechanisms are complex and not yet fully understood, making it a subject particularly well-suited to systems-level modelling. Skills/Qualifications :- A Master's degree in bioinformatics, computational or systems biology, biology with a strong quantitative focus, computer science, applied mathematics or a closely related field. - Programming experience (e.g. Python, R or similar). Solid knowledge of network biology, mathematical modelling and/or omics data analysis. - Excellent command of spoken and written English, as well as good presentation skills. - Strong motivation and a keen interest in pathological mechanisms and translational biomedical research. - Ability to work effectively both independently and as part of an interdisciplinary team. - Knowledge of cellular and molecular biology. Specific requirements: - Experience in logical/Boolean modelling, agent-based modelling or molecular interaction maps is a major asset. - Training in complement system biology, ocular biology or therapeutic reorientation is an asset. - Willingness to travel for secondments to partner institutions. - Ability to work independently. - Languages: ENGLISH
Requirements / required education level / degree: Master Degree or equivalent
Requirements / required education level / discipline: Chemistry
Requirements / required education level / degree: Master Degree or equivalent
Requirements / required education level / discipline: Physics
Requirements / required education level / degree: Master Degree or equivalent
Requirements / required education level / discipline: Biological sciences
Requirements / required languages / language: FRENCH
Requirements / required languages / language level: Basic
Research experience / main research field: Chemistry
Research experience / years of research experience: None
Research experience / main research field: Physics
Research experience / research sub field: Biophysics
Research experience / years of research experience: None
Research experience / main research field: Biological sciences
Research experience / research sub field: Biological engineering
Research experience / years of research experience: None
Additional information / info website: https://emploi.cnrs.fr/Offres/Doctorant/UMR5077-MARPEL1-027/Default.aspx
Work location / nr job positions: 1
Work location / job organisation institute: Unité de biologie moléculaire, cellulaire et du développement
Work location / job country: France
Work location / job city: TOULOUSE
Hiring contact / organisation institute: CNRS
Hiring contact / organisation institute type: Public Research Institution
Hiring contact / division faculty: Unité de biologie moléculaire, cellulaire et du développement
Hiring contact / country: France
Hiring contact / city: TOULOUSE
Hiring contact / website: http://www.cbi-toulouse.fr/
Application / how to apply: website
Application / application website: https://emploi.cnrs.fr/Offres/Doctorant/UMR5077-MARPEL1-027/Default.aspx
EU funding / framework programme: Horizon Europe - MSCA
EU funding / cofund nr job position: 1
Research field / main research field: Chemistry
Research field / main research field: Physics
Research field / sub research field: Biophysics
Research field / main research field: Biological sciences
Research field / sub research field: Biological engineering
Researcher profile: First Stage Researcher (R1)
Positions: Other Positions
Contract: Temporary
Job status: Full-time
Application deadline (as exported; timezone unverified): 2026-11-10T00:00:00