老年性黄斑变性(AMD)光学成像与药物优化方向博士研究员 (DC13)

Development of an ultra-high resolution multimodality imaging system. We are seeking a highly motivated and intellectually curious PhD student to work on a project investigating therapy approaches in Age-Related Macular Degeneration (AMD) disease models. The PhD position is part of the MSCA Doctoral Network PANDORA on discovering Pathomechanisms and Novel Drug Optimization for AMD. The PhD student will focus on advancing resolution, sensitivity and adaptability capabilities of the hybrid microscope already operating at our premises utilizing the proprietary wavefront shaping technology (Wavelens®) allowing precision illumination control in all modalities (Optoacoustic microscopy OAM, two-photon excitation fluorescence TPEF, Second Harmonic Generation SHG and Raman). The aim is to advance the imaging capabilities of a multiparametric, multimodality microscope, by design and integration of the Wavelens system for precision illumination control, achieving sub-diffraction resolution in all modalities. This optical development work will directly support a parallel research effort in the Foundation for Research and Technology (FORTH) investigating multiple AMD diagnostics and therapeutic approaches. AMD is the most common cause of blindness in the elderly population and its pathological mechanisms are complex and not fully understood. The project aims to test multiple therapies including complement inhibition, antioxidants, anti-inflammatory drugs and mitochondria modulators. The results will help design diagnostic paradigms and therapeutic approaches. The PhD candidate will benefit from a network of European experts in different fields (gene therapy, pharmacology, bioinformatics, disease modeling, imaging) and will have the possibility to visit other labs in secondments (lab exchanges). The doctoral candidate will utilize: • Full integration of Wavelens digital lens onto the multimodality microscope allowing for precision illumination control in all modalities (Optoacoustic microscopy OAM, two-photon excitation fluorescence TPEF, Second Harmonic Generation SHG and Raman). • Achievement of sub-diffraction resolution in tissues. • Performance validation in live imaging of AMD molecular biomarkers.

Recent open access research publication related to this position: https://arxiv.org/abs/2509.12840 https://doi.org/10.1038/s44310-024-00036-3 https://doi.org/10.1364/ol.604550

Requirements / required education level / degree: Bachelor Degree or equivalent

Requirements / required education level / discipline: Physics

Requirements / required education level / degree: Bachelor Degree or equivalent

Requirements / required education level / discipline: Engineering

Requirements / required education level / degree: Master Degree or equivalent

Requirements / required education level / discipline: Physics

Requirements / required education level / degree: Master Degree or equivalent

Requirements / required education level / discipline: Physics

Requirements / required education level / degree: Bachelor Degree or equivalent

Requirements / required education level / discipline: Engineering

Requirements / skills: Required • Strong experience in optical system alignment and instrumentation and experimental setup with optical components and detectors. • Experience in optomechanical system design, including CAD (e.g., Fusion360) and precision mechanical assembly/calibration. • Strong problem-solving skills, and ability to work in multidisciplinary, international teams.

Desirable : • Experience with rapid prototyping and 3D printing • Familiarity with optical simulation software (e.g., Zemax) • Prior exposure to biomedical/tissue imaging applications

Requirements / required languages / language: ENGLISH

Requirements / required languages / language level: Excellent

Additional information / benefits: The EU provides a 36 months’ support for each recruited researcher. We offer a highly competitive remuneration package, consisting of: • ​​ Living and mobility allowance: A gross monthly salary of €2,950 (subject to statutory taxes and employee social security deductions) (paid over 14 installments per year). ​ • Monthly family allowance: A family allowance is available for eligible candidates.

Company Overview At Kymatonics, we develop advanced photonic technologies for next-generation imaging and sensing systems. Our work focuses on translating cutting-edge optical research into scalable, high-performance products through the development of the Wavelens programmable optical platform. By joining us, you will contribute to enabling new capabilities in microscopy and biomedical imaging. Kymatonics is an equal opportunity employer committed to open, transparent, and merit-based recruitment in line with the European Commission's OTM-R (Open, Transparent and Merit-based Recruitment) principles and the EURAXESS Code of Conduct, and we particularly encourage applications from women and from researchers belonging to underrepresented groups, with all candidates assessed solely on their qualifications and potential, regardless of gender, ethnicity, religion, age, disability, sexual orientation, or social background. We offer access to modern, state-of the art laboratories, facilities, and equipment, as well as participation in training activities of the international and intersectorial PANDORA network. We also promote participation in national and international conferences.

Additional information / eligibility criteria: The applicant: • Shall not have resided or carried out their main activity (work, studies etc.) in Greece for more than 12 in the 36 months immediately before the recruitment date (unless part of a compulsory national service or a procedure for obtaining refugee status under the Geneva Convention). • Shall not already be in possession of doctoral degree (*). • Can be of any nationality.

*Researchers who have successfully defended their doctoral thesis, but who have not yet formally been awarded the doctoral degree will not be considered eligible.

Additional information / selection process: Doctoral candidates will be selected on scientific qualification and experience, research interest, additional knowledge/skills and their motivations to participate in an intersectoral research-training program.

Additional information / comment: Please send your CV, specifying the title of the position , a 1-page cover letter and the contact details of two academic references to recruitment@kymatonics.com . The use of any AI tool for cover letter drafting should be disclosed.

Work location / nr job positions: 1

Work location / job organisation institute: KYMATONICS

Work location / job country: Greece

Work location / job state province: CRETE

Work location / job city: HERAKLION

Work location / job postal code: 70013

Work location / job street: N. PLASTIRA 100

Hiring contact / organisation institute: Kymatonics

Hiring contact / organisation institute type: Small Medium Enterprise, Start-up

Hiring contact / country: Greece

Hiring contact / city: Heraklion

Hiring contact / state province: Crete

Hiring contact / postal code: 70013

Hiring contact / street: N. Plastira 100

Hiring contact / e mail: recruitment@kymatonics.com

Hiring contact / website: https://kymatonics.com/

Hiring contact / phone: 00302811392118

Application / how to apply: e-mail

Application / application email: recruitment@kymatonics.com

EU funding / framework programme: Horizon Europe - MSCA

EU funding / cofund nr job position: 1

EU funding / job reference number: 101312030

Research field / main research field: Physics

Research field / sub research field: Applied physics

Research field / main research field: Physics

Research field / sub research field: Optics

Research field / main research field: Physics

Researcher profile: First Stage Researcher (R1)

Positions: PhD Positions

Contract: Temporary

Job status: Full-time

Application deadline (as exported; timezone unverified): 2026-11-17T10:00:00