多模态显微镜与病毒感染类器官研究博士研究员（科研助理，薪级 1017）

MERIT (MEtabolic Reprogramming in viral pathogenesis: from Infection to Therapeutic innovations) is an EU-funded MSCA training programme aimed at better understanding how viruses affect the human body. Coordinated by Dr. Adithya Sridhar, Assistant Professor, and Prof. Dr. Dasja Pajkrt, Professor of Pediatric Infectious diseases, from the OrganoVIR Labs at Amsterdam UMC (location AMC), this project brings together 7 academic institutions and 12 associated partners from across Europe. Within MERIT, researchers will take a new, holistic approach that focuses on infections and host metabolism to unravel virus-induced metabolic reprogramming and its impact on human health. The project’s objective lies in understanding the complex interplay between viruses and host cells, focusing on metabolic reprogramming, and long-term consequences of infection. This will be achieved by combining three methodological pillars: human organoids, integrative and spatial omics, and advanced microscopy. Investigating viral interactions within host cells at the single-particle level poses significant challenges due to the resolution limitations of conventional microscopy, particularly in complex organoid tissue sections and lack of multi-modality approach. To overcome these obstacles, it is necessary to develop and apply multi-modal optical microscopy methods, such as fluorescence based super-resolution microscopy and label-free optical diffraction tomography and quantitative phase microscopy. Another important aspect of this project is to perform advance image analysis on correlative datasets to extract the underlying knowledge. The technical aspect of this project aims to integrate two cutting-edge microscopy platforms, photonic chip-based multimodal microscopy and quantitative phase microscopy (QPM)/optical diffraction tomography. These instruments will be used to study viral infections in organoid models (such as gut and brain). Post-imaging, we will conduct advanced image analysis, develop different models for correlative imaging and on label-free images. As part of MSCA-DN the candidate must be open to travel and collaborate with other partners in this project, especially with other DC such as DC 1, DC 6 DC 8 and DC 10. We invite applications for a PhD Research Fellow position in the development of multimodal microscopy for studying viral infection in organoids, available at the Department of Physics of the University of Oslo (UiO). The starting date is no later than 1 April 2027. The fellowship period is three years. No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo. The place of work is the Department of Physics in Blindern, Oslo.

Requirements / required education level / degree: PhD or equivalent

Requirements / required education level / discipline: Biological sciences

Requirements / skills: The Faculty of Mathematics and Natural Sciences has a strategic ambition of being a leading research faculty. Candidates for these fellowships will be selected in accordance with this and expected to be in the upper segment of their class with respect to academic credentials. • Master’s degree or equivalent in physics or engineering or related field in biomedical engineering and biophysics. Foreign completed degree ( M.Sc .-level) corresponding to a minimum of four years in the Norwegian educational system. Master dissertation must be submitted for evaluation by the closing date, • Solid, hands-on experience with experimental optical instrumentation, including the development, alignment, operation and/or application of optical microscopy systems, • Strong background in image analysis or similar scientific data analysis using Python or MATLAB, • An interest in working in a multidisciplinary research group.

Desired qualifications • Background in adapting or development of optical microscopy platforms such as fluorescence based super-resolution microscopy, diffraction tomography or quantitative phase microscopy systems, • Machine learning or AI-assisted analysis of microscopy or other high-dimensional imaging datasets, • Image reconstruction and computational microscopy, including algorithms for super-resolution microscopy, phase retrieval, quantitative phase imaging, or optical diffraction tomography, • Advanced image analysis, including image registration, segmentation, feature extraction, classification, and correlative/multimodal image analysis. • Experience in bioimaging and handling of biological samples, • As the target applications involve organoids and viruses, it is beneficial if the candidate have experience working with various biological specimen such as tissue sections or organoid samples, • Willingness to collaborate within an international research network and undertake research visits, secondments and training activities at partner institutions.

UiO is subject to the Security Act, which governs the organisation's protection of security-sensitive objects and knowledge, in addition to other relevant legislation concerning access to and the handling of sensitive information. Based on this, it is a requirement that successful applicants are security-eligible. We may use background checks as part of our recruitment process. General MERIT eligibility criteria • Candidates must not have been awarded a doctorate previously • Applicants must not have resided or carried out their main activity in the country or recruiting institution for more than 12 months in the 3 years immediately prior to the date of recruitment, 1 April 2027. See https://marie-sklodowska-curie-actions.ec.europa.eu/actions/doctoral-networks • Candidates must meet the entry requirements for admission to the PhD-program of the institution to which they apply, see below for more details.

Language requirement • Fluent oral and written communication skills in English • English requirements for applicants from outside of EU/EEA countries and exemptions from the requirements: https://www.mn.uio.no/english/research/phd/regulations/regulations.html#toc8

In addition to the eligibility criteria above, candidates admitted to the PhD programme at the University of Oslo must fulfill the grade requirements , see www.mn.uio.no/english/research/phd/regulations/regulations.html#toc7 . The norm is as follows: • The average grade point for courses included in the bachelor’s degree must be C or better in the Norwegian educational system, • The average grade point for courses included in the master’s degree must be B or better in the Norwegian educational system, • The master’s thesis must have the grade B or better in the Norwegian educational system.

Personal skills • Ability to work both independently and as part of a team. It is essential that the researcher can effectively communicate with the collaborators within the EU project in the field of biology, • Ability to work precise in a structured manner and swiftly adapts to new tasks, • Good communication and collaboration skills, • Positive attitude and the ability to handle hectic periods and multi-tasking.

Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal skills.

Additional information / benefits: • Exciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge-based societal development, • Committed colleagues in a good working environment, • Good welfare schemes, • Opportunity of up to 1.5 hours a week of exercise during working hours, • A workplace with good development and career opportunities, • An opportunity to take part in a tailor-made pre-MBA programme to develop entrepreneurial and commercial skills and other network-wide training opportunities including conferences and courses, a Personal Development Plan, non-academic coaching, and workshops on topics including ethics and sustainability and AI/LLM, • Membership in the Statens Pensjonskasse, which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes, • Salary in position as PhD Research Fellow, position code 1017, in salary range NOK 550,800-595,000, depending on competence and experience. From the salary, 2% is deducted in statutory contributions to the State Pension Fund.

UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at u io.no . We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues – could you be the next one? We will provide appropriate accommodations should you need them. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures. If you have an immigrant background, a disability, or CV gaps (Norwegian), we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian). The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports. More information about gender equality initiatives at UiO can be found here . We hope you will apply for the position with us. Formal regulations The best qualified candidates will be invited for interviews. Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25 . When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we can't, you will hear from us. Please refer to Regulations for the Act on universities and colleges chapter 3 (Norwegian), Guidelines concerning appointment to post doctoral and research posts at UiO (Norwegian) and Regulations for the degree of Philosophiae Doctor (PhD) at the University of Oslo . The University of Oslo has a transfer agreement with all employees that is intended to secure the rights to all research results etc. For further information please contact: Prof. Balpreet Singh Shluwalia, phone: +4795861441, e-mail: b.s.ahluwalia@fys.uio.no . For questions regarding Jobbnorge, please contact HR Adviser Karoline Hanssen, e-mail: karoline.hanssen@mn.uio.no .

Work location / nr job positions: 1

Work location / job organisation institute: University of Oslo

Work location / job country: Norway

Hiring contact / organisation institute: University of Oslo

Hiring contact / organisation institute type: Higher Education Institute

Hiring contact / country: Norway

Hiring contact / city: Oslo

Hiring contact / website: https://www.mn.uio.no/fysikk/english/

Application / how to apply: website

Application / application website: https://www.merit-eu.org/doctoral-candidate-opportunity-5

EU funding / framework programme: Horizon Europe - MSCA

EU funding / cofund nr job position: 1

Research field / main research field: Biological sciences

Research field / sub research field: Other

Researcher profile: First Stage Researcher (R1)

Positions: PhD Positions

Contract: Temporary

Job status: Full-time

Application deadline (as exported; timezone unverified): 2026-10-30T22:59:00