阿尔茨海默病风险-韧性通路的发现和功能测试博士生职位
PhD Studentship: Discovery and functional testing of Alzheimer’s disease risk–resilience pathways in human iPSC microglia
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 利用计算方法发现与阿尔茨海默病风险和保护相关的分子通路，并进行功能测试
- 申请条件
- 原文未说明
- 待遇
- 提供学费和津贴，研究培训和支持费用，以及每年最高 £5,000 的额外研究资金
- 申请方式
- 原文未说明
- 材料清单
- 原文未说明
由 @cf/meta/llama-3.3-70b-instruct-fp8-fast 生成，博士岗判定置信度 100%。
结构化信息
- 截止
- （Europe/London） 剩 13 天
- 学科
- 神经科学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-05
判定依据（原文摘录）
- is_phd
PhD Studentship
- english_ok
available to UK and International students
原文
The GW4 BioMed3 Doctoral Landscape Programme is offering up to 18 MRC funded studentships across a range of biomedical disciplines, with a start date of October 2027.
These four-year studentships provide funding for fees and stipend at the rate set by the UKRI, as well as other research training and support costs, and are available to UK and International students.
This project is in competition for place with the projects across the MRC GW4 BioMed3 Doctoral Landscape Award studentships. There are a total of 18 studentships available across the partnership.
Late onset Alzheimer’s disease (LOAD) risk is shaped by microglial genes, particularly the TREM2 signalling axis. The coding mutation TREM2 R47H increases disease risk, while the coding mutation in the downstream signalling molecule PLCG2 P522R appears protective. This inverse relationship provides a powerful genetic entry point to identify pathways that drive vulnerability or resilience genome wide. This project will use computational methods to discover molecular pathways showing opposite patterns across risk- and protective-variant human iPSC-derived microglia. The student will prioritise pathways, perturb candidate genes, and test whether these alter microglial effects on neuronal functions relevant to LOAD pathogenesis.
These studentships are funded through GW4 BioMed3 MRC Doctoral Landscape Programme and consist of UK tuition fees, as well as a Doctoral Stipend matching UK Research Council National Minimum (£21, 805 p.a. for 2026/27, updated each year).
Additional research training and support funding of up to £5,000 per annum is also available. Stipend matching UK Research Council National Minimum (£21,805 per annum updated each year) plus UK/Home tuition fees