新单分子工具研究自组装方向博士研究员
PhD Studentship: New Single-Molecule Tools to Study Self-Assembly
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在开发新一代单分子显微镜，结合空间与光谱指纹记录单个分子的位置与光谱，从而研究蛋白质复合物的组装过程、模型系统与细胞中的自组装，并应用于T细胞激活的早期阶段研究。
- 申请条件
- 申请人应持有或预计在项目开始前获得化学、物理或相关学科的强有力本科学位；热爱动手构建仪器、物理化学、编程以及拆解装置。
- 待遇
- 由UKRI资助的3.5年期博士生奖学金，涵盖英国学生的学费和生活津贴（按UKRI标准执行）。
- 申请方式
- 请通过大学在线申请门户网站进行申请，截止日期为2027年1月31日。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 107 天
- 学科
- 化学
- 合同类型
- 雇佣合同
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Joe Beckwith
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-15
- 详情核验
判定依据（原文摘录）
- 这是一项博士生培养机会
You'll be the first PhD student in a newly established group in Warwick Chemistry.
- 英语要求可通过国际招生及英国高校通用英语环境推断，且原文为全英文
Applicants should hold, or expect to obtain, a strong undergraduate degree in Chemistry, Physics or a related discipline by the start of the project.
- 要求本科学位（通常指本科及以上，需结合后续培养要求）
Applicants should hold, or expect to obtain, a strong undergraduate degree in Chemistry, Physics or a related discipline by the start of the project.
原文
Supervisor: Joe Beckwith, joseph.beckwith@warwick.ac.uk . Please contact for informal enquiries.
Research Summary
Proteins rarely work alone. They assemble into complexes, and the order in which they come together can decide whether a cell sends a signal or forms a toxic aggregate. That order is almost impossible to see with bulk methods, which average over millions of molecules. We have developed a microscope (preprint) that records both the position and the spectral fingerprint of individual molecules, letting us tell many molecules apart at once. In this project, you'll build the next generation of this instrument and use it to watch complexes assemble, one molecule at a time.
This will involve:
• Building a new single-molecule microscope. ◦ You’ll learn instrument design, electronics and programming for instrument automation as well as mechanical construction.
• Designing and implementing single-molecule imaging experiments. ◦ You will learn, data (and image) analysis, numerical simulation, and chemical dynamics analyses.
• Imaging self-assembly in model systems and cells. ◦ You will learn cell culture, as well as biophysical sample preparation.
This next generation instrument will then be applied to the earliest stages of T-cell activation: a three-part protein complex assembly that governs how our adaptive immune system responds to threats.
Why this group?
You'll be the first PhD student in a newly established group in Warwick Chemistry. That means hands-on supervision and a real say in how the lab and its work takes shape. Joe recently co-developed the spatial spectral microscope this project builds on, work that is now the subject of a patent application. For more information on the lab, please see jsbeckwith-lab.com.
The group sits at the interface of physical chemistry and biophysics. Alongside immune signalling, we use photothermal and single-molecule methods to study how nanoparticles form. You'll also benefit from our collaborations with groups in Göttingen, Geneva and Durham and links outside academia, giving you a wide network and experience.
Funding Notes
This studentship (3.5 years) is funded by UKRI, covering a stipend and tuition fees, for a UK student, at the UKRI rate. Please contact Joe for further details.
Start Date: October 2027
Application Deadline: 31 January 2027
Eligibility
We welcome applications from all suitably qualified candidates, and particularly encourage applications from under-represented groups. We are seeking someone who enjoys building things, physical chemistry, coding, and taking apparatus apart. Applicants should hold, or expect to obtain, a strong undergraduate degree in Chemistry, Physics or a related discipline by the start of the project.
How to apply Please apply via the university’s online portal by clicking th e'Apply button above.