病理学博士研究员：探讨恶性生殖细胞肿瘤中失调的microRNA介导细胞通路的泛函效应
PhD Studentship: Exploring Functional Effects of Dysregulated MicroRNA-mediated Cellular Pathways in Malignant Germ Cell Tumours
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在工程化诱导型恶性生殖细胞肿瘤（GCT）细胞系中深入研究失调的microRNA介导的细胞通路，扩展前期关于miRNA靶向、过表达或补充的研究观测。同时，将在体内研究前探讨miRNA补充/靶向方法与顺铂的联合治疗，以及针对已识别受影响细胞通路的新型药物。
- 申请条件
- 申请人应持有（或预计获得）相关学科本科荣誉学位或硕士学位，相当于英国二级甲等（2.1）或更高水平。该奖学金仅面向符合英国本土学费标准（Home fees）的学生。此外，申请人必须在面试前满足大学入学的语言要求。
- 待遇
- 全额资助的博士生奖学金，涵盖当前研究委员会标准的生活补助（stipend）以及英国本土大学学费，资助期限从2027年10月起共计4年。
- 申请方式
- 所有申请均须通过大学的申请者门户网站（Applicant Portal）在线提交，针对病理学博士项目（BLPA22），并请在申请及相关通信中注明参考编号PK51398。完整的申请必须在截止日期2026年12月2日之前提交，申请在所有支持文件（包括2份学术推荐信）提交后方视为完整。
- 材料清单
- 2份学术推荐信
- 阐述申请该领域博士动机、研究兴趣与背景以及能为该岗位带来的素质和经验的说明
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 42 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Dr Matthew Murray
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-20
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22)
- 学士学位可申请（或预计获得英国2.1或更高学位的本科荣誉或硕士学位）
Applicants should hold (or expect to obtain) the equivalent of a UK upper 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject.
- 仅限英国本土学费资格申请者
The studentships are available to students who qualify for UK HOME FEES ONLY .
原文
Location: Central Cambridge
Project title: Exploring functional effects of dysregulated microRNA-mediated cellular pathways in malignant germ cell tumours - Dr Matthew Murray.
Malignant germ cell tumours (GCTs) are characterised by microRNA (miRNA) dysregulation. Our studies to date have identified key tumour-suppressor and oncogenic candidate miRNAs warranting further study. We have already targeted/manipulated over-expressed miR-371~373 and miR-302/367 miRNAs and replenished downregulated miRNAs (let-7 and miR-100-5p/125b-5p) in malignant GCT cell lines with phenotypic and genotypic effects. This project will extend those observations in engineered inducible malignant GCT cell lines in vitro which can, e.g., express miR-100-5p/miR-125b-5p upon doxycycline treatment. Combination treatment using miRNA replenishment/targeting approaches with cisplatin will also be investigated, and novel agents targeting identified affected cellular pathways, prior to in vivo studies.
The Department of Pathology has an excellent reputation in pure biological and biomedical research and is offering fully funded* studentships from October 2027 to work with one of the Research Group Leaders in this large and vibrant Department.
All applications should be made online via the University's Applicant Portal for a PhD in Pathology (BLPA22) via the above ' Apply ' button. A completed application must be submitted by the closing date below. An application is only complete when all supporting documents, including the 2 academic references, are submitted.
It is the applicant's responsibility to ensure their referees submit their references before the closing date of the studentship.
The studentships are available to students who qualify for UK HOME FEES ONLY .
Please check for eligibility details using this website: https://www.postgraduate.study.cam.ac.uk/finance/fees/what-my-fee-status
Funding will cover the student's stipend at the current Research Council rate and Home University Fees. The studentship will be funded for 4 years from October 2027.
Applicants should hold (or expect to obtain) the equivalent of a UK upper 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject. The studentship is open to those eligible for the Home rate of University fees. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the language requirements for admission. ( http://www.graduate.study.cam.ac.uk/courses/directory/blpapdpth/requirements )
Please also explain your motivation why you wish to pursue a PhD in this area, outline your research interests and background, and describe the qualities and experience you will bring to the role.
Applications from ineligible candidates will not be considered.
Further information about the course can be found on our website.
Closing date: 2nd December 2026.
Please quote reference PK51398 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Funding will cover the student's stipend at the current Research Council rate and Home University Fees.