诺里奇研究园生物科学博士研究员：多细胞细菌中NLR信号传导的新作用
PhD Studentship: From Defence to Antibiotic production: Uncovering New Roles for NLR Signalling in Multicellular Bacteria
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在挑战细菌NLR仅在噬菌体防御中发挥作用的传统范式，通过结合计算挖掘与实验生物学，探索链霉菌“NLRome”的全面功能，揭示其在多细胞发育、复杂信号网络及天然产物调控中的广泛作用。
- 申请条件
- 申请者需至少持有英国同等标准的学士（荣誉）2:1学位。满足理学院英语语言要求（总分6.5分，各单项不低于6分）。
- 待遇
- 提供4年制Norwich Research Park Biosciences Doctoral Training Partnership博士奖学金，包含学费、生活津贴（2026/27年度津贴标准为每年21,805英镑）以及每年5,000英镑的研究培训支持补助金。
- 申请方式
- 欢迎通过电子邮件向Prof Susan Schlimpert（susan.schlimpert@jic.ac.uk）进行非正式咨询。原文未说明具体的网申地址、截止日期或提交语言要求。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Susan Schlimpert
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 英语要求
English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
- 允许学士学位申请
At least UK equivalence Bachelors (Honours) 2:1.
原文
Nucleotide-binding and oligomerisation domain-like receptors (NLRs) are famous for driving immune responses in plants and animals. However, their extensive presence in multicellular, antibiotic-producing Streptomyces hints at a much richer, untapped functional diversity. This PhD project aims to challenge the paradigm that bacterial NLRs solely function in phage defence, uncovering their broader roles in multicellular development, complex signalling networks, and the regulation of natural products.
By combining computational mining with hands-on experimental biology, you will explore the full spectrum of the Streptomyces ""NLRome"". You will deploy synthetic activation tools to trigger candidate NLRs, investigating how they control bacterial viability, phage immunity, morphological development, and antibiotic biosynthesis. Beyond fundamental biology, this project holds high-impact applied potential: synthetic activation of specific NLRs offers a novel route to switch on silent gene clusters and trigger the production of new bioactive molecules.
As a PhD researcher on this project, you will gain comprehensive, interdisciplinary training across:
• Computational Biology & Bioinformatics: Large-scale genome mining, structural modelling (AlphaFold, Foldseek), and pipeline development.
• Molecular Microbiology & Genetics: Phenotyping, heterologous expression, phage assays, and genetic engineering of multicellular bacteria.
• Protein Biochemistry & Omics: Protein-protein interaction studies, catalytic assays, transcriptomics, and metabolomics.
Based at the John Innes Centre, you will join a supportive, highly collaborative research environment supported by world-class platform facilities and leading experts in plant and bacterial NLR biology.
You will also develop key professional skills through conference presentations, manuscript preparation, and public science outreach.
This project is ideal for a motivated student eager to blend computational analysis with experimental biology to redefine our understanding of ancient signalling proteins.
Informal enquiries to Prof Susan Schlimpert ( susan.schlimpert@jic.ac.uk ) are welcome.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
Mode of study
Full-time
Start date
1 October 2027
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship. £21,805 and a Research Training Support Grant of £5,000pa for each year of the studentship.