妊娠期大肠杆菌相关尿路感染的一体化健康（宏）基因组学博士研究员
PhD Studentship: One Health (meta)genomics of E. coli-associated Urinary Tract Infections in Pregnancy
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目研究妊娠期尿路感染风险增加是否部分由于引起感染的大肠杆菌类型差异（包括系统发育群、毒力基因和抗微生物耐药性决定因素）所致。学生将与诺福克和诺里奇大学医院的临床医生合作，收集孕妇的尿液和粪便样本，并使用长读长基因组和宏基因组测序、18S qPCR以及细胞因子定量来表征微生物组成和评估疾病严重程度。全基因组序列数据将用于将UTI致病大肠杆菌基因型与患者自身肠道、非孕妇公开基因组以及食品和环境来源进行比较，以探讨感染来源。
- 申请条件
- 原文未说明具体学位或专业申请条件。
- 待遇
- 提供为期4年的Norwich Research Park Biosciences Doctoral Training Partnership博士生奖学金，包含直接支付给学校的学费、用于生活费的津贴（2026/27学年津贴标准为每年21,805英镑）以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 请点击上方“Apply”按钮获取进一步信息并进行申请。申请截止日期为2026年11月30日23:59。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 免疫与微生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
- 奖学金及生活津贴明细
The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.
原文
Urinary tract infections (UTIs) affect up to 35% of pregnant women and are associated with maternal sepsis, pre‑term birth and markedly higher health‑care costs. Uropathogenic Escherichia coli (UPEC) accounts for 82–85% of these infections, and there are various bacterial factors that predispose to higher infection morbidity including certain phylogenetic groups, sequence types and virulence factors.
In this project, the student will investigate the hypothesis that the increased risk of UTIs observed in pregnancy may be in part due to differences in the types of E. coli causing the infections, including variations in phylogenetic group, virulence genes and antimicrobial resistance (AMR) determinants. Working with clinicians at the Norfolk and Norwich University Hospital, the student will collect urine and faecal samples from pregnant women, and use long-read genome and metagenome sequencing to characterise urine microbial compositions in these groups and 18S qPCR to examine human DNA load and cytokine quantification to evaluate disease severity. Whole genome sequence data will be used to obtain an understanding of where the infections might be coming from: the genotypes of UTI-causing E. coli will be compared with 1) those in the patients’ own guts, 2) publicly available genomes obtained from non-pregnant individuals, 3) E. coli genomes from food and other environmental sources, as it’s been suggested some infections might come through the food chain.
The outcomes from this One Health and microbiome project will help combat infectious disease and antimicrobial resistance, and will provide the student with a valuable skillset in interdisciplinary research, encompassing bioinformatics, (meta)genomics and statistics with public health relevance.
Funding Details
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.
For further information please click on the ' Apply ' button above.
Closing Date: 23:59 on 30 November 2026 £21,805 p.a.