蛋白质糖基化在细菌定植与肠道适应中的作用博士研究员
PhD Studentship: Sweet and Sticky: The Role of Protein Glycosylation in Bacteria Colonisation and Adaptation to the Gut
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在利用体外和体内方法（包括类器官芯片技术和老鼠模型），研究蛋白质糖基化（特别是丝氨酸重复蛋白SRRPs）在细菌生物膜形成和肠道定植中的作用，探讨其在罗伊氏乳杆菌适应肠道过程中的机制。
- 申请条件
- 原文未说明具体申请学历或专业先决条件，但属于Norwich Research Park Biosciences Doctoral Training Partnership (NRP DTP) 4年制博士项目。
- 待遇
- 提供4年期Norwich Research Park Biosciences Doctoral Training Partnership (NRP DTP) 博士奖学金，包含全额学费、生活津贴（2026/27学年标准为每年21,805英镑）以及每年5,000英镑的研究与培训支持补助金（RTSG）。
- 申请方式
- 原文未说明具体的申请方式、截止日期及提交要求。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一个博士培养机会
This PhD studentship provides an exciting opportunity for the successful candidate to address fundamental questions on the role of protein glycosylation in bacteria adaptation in the gut.
原文
The accessory secretion (aSec) system is a protein export pathway that is uniquely present in Gram-positive bacteria and is dedicated to the secretion of large, glycosylated cell wall-anchored adhesins called serine-rich repeat proteins (SRRPs). We previously identified aSec pathways and strain-specific glycosylation of SRRPs in Limosilactobacillus reuteri, a health-promoting gut commensal bacteria showing high host specialisation. This PhD studentship provides an exciting opportunity for the successful candidate to address fundamental questions on the role of protein glycosylation in bacteria adaptation in the gut.
In this PhD project, the student will use in vitro and in vivo approaches including organ-on-chip technology and mouse models to investigate the role of SRRP glycosylation in biofilm formation and colonisation.
The PhD student will join a large and dynamic multidisciplinary team at the Quadram Institute Bioscience and receive mentoring and training in relevant experimental models and state-of-the art analytical tools. Through this PhD studentship, the student will acquire expertise in molecular microbiology, glycobiology, biochemistry, imaging, bioinformatics, advanced microbe-host models (gut organoids) and in vivo skills.
The student will benefit from the established network of international collaborations of the host Labs in this research area. Training will embrace research practice and theory, research integrity, management, communication (to scientific and lay audiences) and technical writing, intellectual property, teamwork. The student will present his/her work at internal seminars and to relevant Microbiology and Glycobiology international meetings, and be encouraged to participate into outreach activities and innovative competitions.
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: 21,805, and a Research Training Support Grant of 5,000pa for each year of the studentship. £21,805 and a Research Training Support Grant of 5,000pa for each year of the studentship.