小麦锈病免疫关键调控因子解析博士研究员
PhD Studentship: Deciphering Critical Regulators in Wheat Rust Immunity
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在阐明支链氨基酸（BCAAs）可用性如何激活水杨酸（SA）介导的防御和/或调节植物中的代谢信号，具体包括：（i）解析BCAA积累与激活TaASIL1功能之间未知的联系，以及（ii）表征TaASIL1的其他BCAA依赖性基因靶标。
- 申请条件
- 申请者需具备至少英国同等学力的本科学士（荣誉）2:1学位。同时须满足英语语言要求（科学学院同等标准：雅思总分 6.5，各单项不低于 6）。
- 待遇
- 该项目提供为期4年的Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) 博士奖学金，包含学费全免、每年生活费津贴（2026/27年度津贴标准为每年21,805英镑）以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 原文未说明具体的申请网址与截止日期，请参考相关博士培养计划的官方申请指引。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 农业与食品
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
- 英语要求
English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
- 学士学位即可申请
At least UK equivalence Bachelors (Honours) 2:1.
原文
Successful plant pathogens hijack plant metabolism and biosynthetic pathways to enrich nutrient availability. However, exploiting host physiology creates changes in metabolites that plants can sense and interpret as indicators of pathogen infection. This includes branched chain amino acids (BCAAs), which represent important energy sources for pathogens, yet BCAA accumulation in plants also increases levels of the defence compound salicylic acid (SA), which plays a central role in directing immune signaling against biotrophic pathogens. We previously showed in bread wheat (Triticum aestivum), that infection by the biotrophic yellow rust pathogen (Puccinia striiformis f. sp. tritici; Pst) upregulates the gene for BCAA AMINOTRANSFERASE 1 (TaBCAT1), which modulates catabolism of BCAAs to prevent BCAA accumulation and promote Pst colonisation. In contrast, disrupting TaBCAT1 function leads to hyperaccumulation of BCAAs and SA, resulting in reduced susceptibility to Pst. Furthermore, we found that BCAA-mediated SA accumulation is dependent on a MYB/SANT transcription factor (TF), termed TaASIL1, which represses expression of TaSIZ1, a SUMO E3 ligase that is a key negative regulator of SA homeostasis. However, how BCAA accumulation enhances TaASIL1 activity remains to be resolved.
The aim of this proposal is to elucidate how BCAA availability activates SA-mediated defence and/or modulates metabolic signalling in plants, by: (i) resolving the unknown link between BCAA accumulation and activation of TaASIL1 function, and (ii) characterising additional BCAA-dependant gene targets of TaASIL1. This research will ultimately determine how MYB TFs mediate environmental signals, such as BCAAs, to modulate metabolic signalling in plants and provide critical new insight into basal plant defence responses in wheat.
The student will be embedded in the Saunders Lab at the John Innes Centre, which is a multidisciplinary research lab, providing the opportunity to develop extensive skills in a breadth of areas, including plant pathology, wheat genetics, molecular biology, and bioinformatics.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
Mode of study
Full-time
Start date
1 October 2027
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship. £21,805 and a Research Training Support Grant of £5,000pa for each year of the studentship.