突变造血干细胞如何损害其健康邻近细胞方向博士研究员
PhD Studentship: A Hostile Niche: How Mutant Blood Stem Cells Damage Their Healthy Neighbours
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在了解血液系统的哪些细胞受到影响，以及这些细胞在基因和代谢水平上发生了什么变化，最终目标是弄清楚这是否会导致正常血细胞的加速衰老。
- 申请条件
- 要求申请者具备分子或细胞生物学、免疫学、遗传学或相关生物科学专业的背景，并对干细胞生物学或衰老感兴趣。
- 待遇
- 提供为期4年的Norwich Research Park Biosciences博士生培训伙伴关系（DTP）奖学金，包含学费、每年21,805英镑的生活津贴（2026/27年度标准）以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 申请人需通过点击上方的“Apply”按钮进行申请，截止时间为2026年11月30日23:59。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
原文
As people age, some blood stem cells acquire mutations that give them a growth advantage over their normal counterparts. Our recent work suggests the mutant cells don't just outgrow their neighbours, they actively reshape the bone marrow around them. This change causes a functional change in the normal blood stem cells skewing their production of the immune cells. This project aims to understand which cells of the blood system are affected and what is happening to the cells at the gene and metabolic level with the overarching aim of understanding if this causes accelerated ageing of the normal blood cells.
The successful candidate will build a broad and transferable skillset: designing flow cytometry experiments across the full blood hierarchy, tissue culture, in-vivo modelling, gene expression profiles by RNA-sequencing, and metabolic assays. They will be fully integrated into a collaborative, well-supported research group spanning stem cell biology and metabolism, with regular lab meetings, journal clubs and opportunities to present their work across the Norwich Research Park and at national and international meetings.
This is a highly interdisciplinary project, ideal for someone with a background in molecular or cell biology, immunology, genetics or a related bioscience discipline, and an interest in stem cell biology or ageing. You will be based in the Mistry and Rushworth Lab at Norwich Medical School, UEA, working alongside expert collaborators at the Earlham Institute and across the Norwich Research Park.
Funding Details
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.
For further information please click on the ' Apply ' button above.
Closing Date: 23:59 on 30 November 2026. £21,805 p.a.