多药外排进化中指挥链破解的博士研究员
PhD Studentship: Cracking the Chain of Command in Multidrug Efflux Evolution
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 该博士项目探索细菌如何进化出多药耐药性，研究大肠杆菌及其他细菌中多药外排系统的层级关系，测试这种层级是否具有条件依赖性且可改变。利用包含80万以上突变体的庞大转座子文库，绘制厌氧生长、生物膜、血清等多种条件下的适应度影响，探索泵的去除如何重塑耐药层级并分离功能成本与调控成本。
- 申请条件
- 原文未说明具体学位等级及专业背景要求，但项目依托于博士生培养伙伴关系。
- 待遇
- 提供4年制 Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) 博士生奖学金。奖学金包括直接支付给大学的学费、用于生活开支的生活津贴（2026/27学年津贴标准为每年21,805英镑），以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 原文未说明具体的申请方式、网址及截止日期。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 免疫与微生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Mark Webber, Gemma Langridge
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一个博士培养机会
PhD Studentship: Cracking the Chain of Command in Multidrug Efflux Evolution
- 工作语言为英语
Join Professor Mark Webber and Dr Gemma Langridge at the Quadram Institute Bioscience for a cutting-edge PhD project exploring how bacteria evolve multidrug resistance.
原文
Are you passionate about understanding antibiotic resistance at the molecular level? Join Professor Mark Webber and Dr Gemma Langridge at the Quadram Institute Bioscience for a cutting-edge PhD project exploring how bacteria evolve multidrug resistance.
Bacteria carry multiple efflux pumps, yet only a few dominate resistance in clinical isolates. Why this is the case is unclear. This project will investigate the hierarchy of multidrug efflux systems in E. coli and beyond, testing whether this hierarchy is condition-dependent and alterable.
Using a massive transposon library of 800,000+ mutants, you'll map fitness impacts across diverse conditions—anaerobic growth, biofilms, serum, and more. You'll explore how pump removal reshapes resistance hierarchies and separate functional from regulatory costs.
You'll gain expert training in microbial evolution, genetics, transposon mutagenesis, and bioinformatics. You will be based within the state-of-the-art Quadram Institute building located on the Norwich Research Park, which host the Centre for Microbial Interactions, a vibrant research community of over 100 microbiology research groups. The project offers a wide range of opportunities for training and personal development in a world class environment.
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.