诺里奇研究园生物科学博士生培训伙伴关系（NRPDTP）博士研究员：发现下一代抗生素
PhD Studentship: Discovering the Next Generation of Antibiotics
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在通过系统性地靶向控制特殊代谢物生成的调控网络，利用遗传学方法在实验室条件下激活链霉菌基因组中编码的沉默隐蔽途径，从而发现具有新作用机制的新型抗生素化合物。候选人将在分子微生物学、天然产物化学、抗微生物耐药性、生化分析和生物信息学等前沿领域接受培训。
- 申请条件
- 原文未明确列出具体的学位等级或专业背景门槛要求，但属于4年制诺里奇研究园生物科学博士生培训伙伴关系（NRPDTP）项目。
- 待遇
- 提供为期4年的Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) 博士生奖学金。奖学金包含直接向大学支付的学费、用于涵盖生活费用的津贴（2026/27学年津贴标准为每年21,805英镑），以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 原文未说明具体的申请方式、提交语言或在线申请地址。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 免疫与微生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一个博士培养机会
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
原文
The continued evolution of antibiotic-resistant bacteria presents a significant threat to global health and new compounds with novel mechanisms of action are urgently needed. Most clinical antibiotics are derived from the specialised metabolites of Streptomyces strains, and on average a single Streptomyces strain encodes between 25-50 biosynthetic gene clusters (BGCs) which encode for their production; many of these molecules will have antibiotic activity. However, more than 90% of these encoded specialised metabolites are not produced under laboratory conditions, meaning many new compounds remain to be discovered. To access the full metabolic potential of Streptomyces species, cryptic pathways encoding new molecules must be switched on under laboratory conditions.
In this crossdisciplinarity project the successful candidate will use genetic methods to systematically target the regulatory networks controlling specialised metabolite production. This will lead to new methods for accessing the silent arsenal of cryptic antibiotics encoded in bacterial genomes. They will develop an understanding of antibiotic function, discovery & development in addition to cutting edge training in molecular microbiology, natural products chemistry, antimicrobial resistance, biochemical analysis, and bioinformatics. These skills are essential to the next generation of bioscientists, and the candidate will be further supported in acquiring transferable skills such as written and spoken communication, problem solving and critical thinking and will help train visitors to the lab so s/he can gain skills in knowledge exchange. This combination of skills and experience will make the successful candidate highly employable in both academia and industry.
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.