健康衰老博士研究员：利用蛋白质稳态途径促进细胞外基质功能
PhD Studentship: Unlocking healthy ageing: harnessing proteostasis pathways to promote extracellular matrix function
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目将测试在衰老过程中激活应激反应对细胞外基质（ECM）组成、结构和功能的影响，并确定这些变化是否能延长健康寿命。
- 申请条件
- 我们正在寻找一位对衰老生物学和遗传学有浓厚兴趣、充满热情且高度积极的个人。
- 待遇
- 该项目获得为期4年的Norwich Research Park Biosciences博士生培训伙伴关系（DTP）博士奖学金资助。奖学金包括支付学费（直接付给大学）、用于支付生活费用的津贴（2026/27学年津贴标准为£21,805），以及每年£5,000的研究培训支持专项经费（RTSG）。
- 申请方式
- 原文未说明具体的申请方式与截止提交细节。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生命科学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一个博士培养项目
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
- 使用英语进行科研培训且未限制其他本地语言
You will gain a wide range of skills in experimental design, bioinformatics, scientific writing and presentation.
原文
Background
Ageing causes increased frailty and higher rates of disease. As societies age, this presents an enormous public health challenge, making understanding the ageing process critically important to develop ways to promote age-related health.
One prominent characteristic of ageing is altered extracellular matrix (ECM) structure and function. Changes in ECM properties have been implicated in age-related conditions including cancer, hypertension and stroke, suggesting that therapies targeting the ECM hold high potential to treat age-associated disease.
Another cause of age-related frailty and disease is a collapse in cellular stress responses, molecular pathways that safeguard cellular health. In fact, recent studies show that driving stress response activation increases longevity and resilience, emphasising their core role in healthy ageing. However, how stress responses may affect ECM ageing remains unexplored.
Our preliminary evidence suggests that driving activation of a key stress response in the model organism Caenorhabditis elegans influences expression of ECM components and promotes healthy ageing. This project will test the effects of stress response activation on composition, structure and function of the ECM during ageing, and determine whether these changes drive prolonged healthspan.
Methodology
You will utilise transcriptomics and proteomics to determine ECM composition, and advanced imaging techniques including confocal microscopy and transmission electron microscopy to examine ECM structure. You will also use genetic approaches coupled with physiological and survival assays to understand how changes to ECM function influence healthspan.
Training
You will gain a wide range of skills in experimental design, bioinformatics, scientific writing and presentation. You will also build expertise in ageing biology, cell biology, ‘omics approaches and genetic techniques. In addition, you will participate in external training courses and conferences, local seminars, research discussion groups and journal clubs.
Person specification
We are looking for an enthusiastic and highly motivated individual with a strong interest in ageing biology and genetics.
Additional Funding Information
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000 pa for each year of the studentship.