关于NRP2如何在应激下保持血管封闭和稳定的博士研究员
PhD Studentship: How does NRP2 keep blood vessels sealed and calm under stress?
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目研究神经纤毛蛋白-2（NRP2）如何控制人源及小鼠内皮细胞中的内皮屏障稳定性，探讨细胞对血流、炎症刺激以及脂质/营养应激的反应，并利用内皮特异性小鼠模型测试NRP2是否在体内帮助血管适应饮食应激。
- 申请条件
- 申请者需具备英国同等学历的学士（荣誉）2:1及以上学位。满足理学院同等英语语言要求（雅思总分6.5，单项不低于6）。
- 待遇
- 提供为期4年的Norwich Research Park Biosciences Doctoral Training Partnership博士生奖学金，包含直接支付给学校的学费、生活费津贴（2026/27年度津贴标准为每年21,805英镑）以及每年5,000英镑的研究培训支持金（RTSG）。
- 申请方式
- 原文未说明具体的申请提交流程、网址或材料格式，截止日期为2026年11月30日，入学时间为2027年10月1日。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生命科学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
This PhD project will investigate neuropilin-2, or NRP2, a cell-surface receptor best known for roles in blood vessel development.
- 英语要求
English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
- 允许学士学位申请
At least UK equivalence Bachelors (Honours) 2:1.
原文
Blood vessels are lined by endothelial cells, which form a living barrier between blood and tissues. These cells must stay tightly connected, sense blood flow, respond to nutrients and communicate with immune cells, while avoiding unnecessary inflammation. How endothelial cells maintain this stable “barrier identity” during stress is still not fully understood.
This PhD project will investigate neuropilin-2, or NRP2, a cell-surface receptor best known for roles in blood vessel development. Our new data suggest that NRP2 also helps endothelial cells stay stable. When NRP2 is lost, endothelial cells lose the junctional protein VE-cadherin, become more inflammatory and show increased adhesion molecules that can recruit immune cells.
The student will test how NRP2 controls endothelial barrier stability in human and mouse endothelial cells. They will study how cells respond to flow, inflammatory stimulation and lipid/nutrient stress, and will ask whether loss of VE-cadherin is the trigger that drives inflammatory activation. The project will also use an endothelial-specific mouse model to test whether NRP2 helps blood vessels adapt to dietary stress in vivo.
The student will receive broad interdisciplinary training in endothelial cell biology, receptor trafficking, live-cell and confocal imaging, flow assays, inflammatory signalling, monocyte adhesion, mouse genetics, vascular physiology, statistics and data interpretation. The project is suited to a student interested in cell biology, vascular biology, inflammation and mechanisms that preserve tissue health.
This is a mechanistic PhD project with strong preliminary data, clear aims and room for the student to shape the direction of the work.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
Mode of study
Full-time
Start date
1 October 2027
Additional Funding Information
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000 pa for each year of the studentship.