性别对抗选择的功能基因组学博士研究员
PhD Studentship: Functional Genomics of Sexually Antagonistic Selection
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在超越单纯寻找性对抗基因的阶段，揭示其特殊之处、对适应度和生活史性状的影响，以及性别冲突及其解决的分子机制。研究将结合前沿生物信息学、基因组工程和最先进的测序技术，在果蝇中开展相关研究。
- 申请条件
- 原文未说明具体申请条件。
- 待遇
- 提供4年期Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) 博士生奖学金，包含直接支付给学校的学费、2026/27年度生活津贴每年21,805英镑，以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 截止日期为2026年11月30日，申请方式原文未说明。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
This PhD offers the scope to develop independence
- 项目提供奖学金资助
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
原文
Why do harmful genes persist in populations instead of being removed by natural selection? One answer lies in sexual antagonism: when a genetic variant benefits males but harms females, or vice versa. This genetic tug-of-war is one of evolution’s most intriguing puzzles. It can create a burden on populations, influence human health, and even help maintain the variation needed for species to adapt to new environments.
Recent work from the supervisor’s lab has revealed consistent sets of sexually antagonistic genes across independent studies in the fruit fly Drosophila melanogaster. This project will take the next big step: moving from finding sexually antagonistic genes to uncovering what makes them special, how they affect fitness and life history traits, and the molecular mechanisms of the sexual conflict and its resolution.
You will combine cutting-edge bioinformatics, genome engineering, and state-of-the-art sequencing technologies to:
• Identify and characterise consistent sexually antagonistic loci across multiple studies.
• Validate their effects on sex-specific fitness and traits using CRISPR-Cas9 allele swaps in fruit flies.
• Probe underlying mechanisms, from gene regulation to alternative splicing.
This PhD offers the scope to develop independence – pursing promising leads on interesting biology – while addressing one of evolution’s most longstanding challenges. Beyond advancing fundamental evolutionary biology, the project has broad relevance to conservation, pest management, aging, and human health. For example, many sex-specific disease phenotypes are maintained due to their genetic bases having sexually antagonistic fitness benefits in the opposite sex.
You will receive outstanding interdisciplinary training in bioinformatics, molecular genetics, and functional genomics. The supervisory team offers expertise spanning evolutionary genetics, bioinformatics, biological statistics, and CRISPR genome engineering. Additional training and collaborative opportunities are available at neighbouring institutes throughout the broader Norwich Research Park in areas such as long-read sequencing and single-cell transcriptomics.
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.