造血干细胞代谢衰老方向博士研究员
PhD Studentship: Running on Empty: Metabolic Ageing in Blood Stem Cells
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在探讨衰老生物学中的一个基本问题：为什么造血干细胞随着年龄增长会出现代谢燃料不足，以及我们是否能进行干预；重点关注谷氨酰胺，揭示其供应随年龄衰减的原因以及恢复它是否能逆转干细胞衰退。
- 申请条件
- 申请者需具备至少英国同等学士学位（荣誉）2:1；满足理学院同等英语语言要求（雅思总分6.5，各单项不低于6）。
- 待遇
- 提供为期4年的Norwich Research Park生物科学博士培训伙伴关系（DTP）博士奖学金，包含直接支付给学校的学费、生活津贴（2026/27年度津贴标准为每年21,805英镑），以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 原文未说明具体申请方式与截止日期，请参考相关DTP官方网站或机构说明进行申请。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 确认为博士培养机会
PhD Studentship: Running on Empty: Metabolic Ageing in Blood Stem Cells
- 英语要求
English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
- 学士学位要求
At least UK equivalence Bachelors (Honours) 2:1.
原文
Every blood cell in your body, from oxygen-carrying red cells to virus-fighting white cells, begins life in a rare population of blood stem cells that must stay active for an entire lifetime. As we age, these stem cells lose their edge, contributing to the immune decline and blood disorders associated with growing older. This project tackles a fundamental question in ageing biology: why do blood stem cells run low on metabolic fuel as we age, and can we intervene? You will focus on glutamine, a nutrient we have shown is essential for healthy blood stem cell function, to uncover why its supply falters with age and whether restoring it can reverse stem-cell decline.
Our previous work revealed that an ageing bone marrow environment blunts immune responses in older individuals. Exciting new data now show that blood stem cells themselves also develop intrinsic metabolic defects. This project will be among the first to pin down these cell-intrinsic changes and test directly whether they compromise stem-cell function and blood output, opening a new route to understanding, and potentially reversing, age-related decline in the blood system.
You will receive comprehensive, hands-on training in a broad and highly sought-after skillset: primary cell isolation, in-vivo and in-vitro modelling, metabolomics, stable isotope tracing, flow cytometry (FACS), LC-MS-based metabolite analysis, qPCR, western blotting, ELISA and metabolic flux analysis. This multidisciplinary training will set you up for a competitive career in academic, clinical or industry research.
You will be based in the Rushworth Lab at Norwich Medical School, UEA, a dynamic, well-funded research group with a strong record of high-impact publications and PhD training success, working alongside expert collaborators at the Earlham Institute and across the Norwich Research Park, one of Europe’s leading centres for life-science research.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
Mode of study
Full-time
Start date
1 October 2027
Additional Funding Information
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000 pa for each year of the studentship.