利用工程生物学方法开发蛋白质纳米笼用于生物技术应用的博士研究员
PhD Studentship: Engineering protein nanocages for biotechnology applications
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在利用工程生物学方法开发细菌和人类铁蛋白作为纳米笼平台，用于包封小分子、肽和蛋白质，并应用于生物催化及治疗与诊断。研究将优化包封方法，并探究纳米笼跨蛋白质外壳传输底物、电子和质子的能力。最终目标包括氢化酶等技术相关酶的应用以及治疗与诊断分子的靶向递送。项目涉及蛋白质纯化、生物分析方法、光谱学、质谱学和显微镜学等。
- 申请条件
- 申请人需具备英国同等学力荣誉学士学位（2:1及以上）。满足理学院同等英语语言要求（雅思总分6.5，单项不低于6）。
- 待遇
- 提供4年期诺维奇研究园生物科学博士培训伙伴关系（NRP DTP）博士奖学金。奖学金包含直接支付给大学的学费、用于生活开销的津贴（2026/27年度津贴标准为每年21,805英镑），以及每年5,000英镑的研究培训支持金（RTSG）。
- 申请方式
- 原文未说明具体的申请方式与提交截止日期，仅提及可向Prof Nick Le Brun（n.le-brun@uea.ac.uk）进行非正式咨询。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Prof Nick Le Brun
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
- 允许仅持学士学位申请
At least UK equivalence Bachelors (Honours) 2:1.
- 英语要求
English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
原文
Proteins that self-assemble to yield cage-like structures are of great interest due to their potential applications in biotechnology. The cellular protein ferritin, which functions to detoxify and store iron, is composed of 24 subunits, arranged in a highly symmetric fashion to form an approximately spherical protein shell surrounding a hollow centre. While evolved to store large amounts of iron as a ferric-oxy-hydroxide mineral, the ferritin protein shell can potentially accommodate a range of other molecules. The aim of this project is to use engineering biology approaches to develop bacterial and human ferritins as nanocage platforms for the encapsulation of small molecules, peptides and proteins with applications in biocatalysis and therapeutics/diagnostics. Methodologies for encapsulation will be optimised, and the ability of the nanocages to transfer substrates, electrons and protons across the protein coat investigated. Eventual targets include technologically relevant enzymes such as hydrogenase, which catalyses the reduction of protons to hydrogen gas, and the targeted delivery of molecules for therapeutic and diagnostic applications. This multi-disciplinary protein biochemistry project, which is based in the Le Brun lab in the School of Chemistry, Pharmacy and Pharmacology at UEA, will involve protein purification, bioanalytical methods, spectroscopy, mass spectrometry and microscopy. It offers excellent training potential for the appointed student within a supportive and stimulating environment. Informal enquiries to Prof Nick Le Brun ( n.le-brun@uea.ac.uk ) are welcome.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
Mode of study
Full-time
Start date
1 October 2027
Additional Funding Information
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000 pa for each year of the studentship.
.