基因转移体生物学博士研究员（Norwich Research Park Biosciences DTP）
PhD Studentship: Breaking Code: Deciphering the Biology of the Selfless Virus-like Gene Transfer Agents
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在深入理解基本的基因转移体（GTA）生物学，并表征遗传信息的驯化过程，以指导合成GTA颗粒的开发和工程改造。学生将接受分子微生物学、荧光显微镜、组学、蛋白质-蛋白质相互作用研究和结构生物学等多学科培训。
- 申请条件
- 申请者需具备生物科学相关背景，且持有英国同等学历的学士（荣誉）学位2:1或以上。英语语言要求达到理学院同等水平（总分不低于6.5分，各单项不低于6分）。
- 待遇
- 提供为期4年的Norwich Research Park Biosciences博士培训伙伴关系（DTP）奖学金。奖学金包括直接支付给大学的学费、用于生活费的津贴（2026/27年度津贴标准为每年21,805英镑），以及每年5,000英镑的研究培训支持补助金（RTSG）。
- 申请方式
- 原文未说明具体的申请提交流程和截止日期，仅提及可向 tung.le@jic.ac.uk 进行非正式咨询。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 37 天
- 学科
- 生物化学、遗传与分子生物学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Tung Le
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-23
- 详情核验
判定依据（原文摘录）
- 这是一项博士培养机会
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
- 英语要求
English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
- 学士学位即可申请
At least UK equivalence Bachelors (Honours) 2:1.
原文
Bacteria commonly exchange genetic information (DNA) in a process called horizontal gene transfer as they evolve and adapt to changes in their local environment. Understanding horizontal gene transfer and how new genetic information is incorporated and domesticated into the existing signalling network and physiology of the host is a fundamental problem in biology. Horizontal gene transfer also contributes to the spread of antimicrobial resistance, which is a leading cause of mortality worldwide. The widespread but so far neglected Gene Transfer Agents (GTAs) are peculiar virus-like particles that were domesticated from ancestral bacterial viruses to now serve as nanomachines for the host bacteria. GTAs facilitate the exchange of genetic information by packaging and disseminating the DNA of the host bacteria. GTAs have a unique but poorly characterized lifecycle yet present an excellent opportunity to study the fascinating biology and fundamentals of domestication of genetic information, and to engineer GTA for biotechnological or therapeutic purposes.
Several key advances from the community and my group now make it timely to investigate and exploit GTA biology. Building on these key advances, the student will aim to develop a better understanding of fundamental GTA biology and to characterize the process of domestication of genetic information to inform the development and engineering of synthetic GTA particles.
The project comes with a multidisciplinary training, including molecular microbiology, fluorescence microscopy, omics, protein-protein interaction studies and structural biology. This will provide you highly transferrable skills and a wide choice of career options.
You will be based in the laboratory of Prof. Tung Le (www.tunglelab.org) in the Department of Molecular Microbiology at the John Innes Centre, a world-class institute for plant and microbial research.
Applications are welcomed from students across the biological sciences who have a desire to work on a multidisciplinary project. Informal enquiries to tung.le@jic.ac.uk are welcome.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
Mode of study
Full-time
Start date
1 October 2027
Additional Funding Information
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.