非经典自噬在不健康饮食引起的肝脏脂质代谢中的作用博士研究员

Primary Supervisor - Professor Naiara Beraza

Obesity has epidemic proportions in the UK as more than 60% of adults are overweight and 33% have fatty liver. Poor dietary habits (western diets) are the main contributors to obesity and liver steatosis, where lipid accumulation becomes toxic for hepatocytes leading to cell death and consequent inflammation. Autophagy, which removes intracellular components, is key to regulate lipid metabolism in hepatocytes and its impairment contributes to fatty liver. Importantly, the role of alternative cellular mechanisms of intracellular cargo degradation like LC3-associated phagocytosis (LAP), remains poorly studied in this context.

This project aims to define the mechanisms mediating the lipid update and metabolism in the liver in response to high fat diets. This will enable the PhD student to identify targets to preserve liver metabolic health and prevent disease progression associated to poor dietary habits, which will be investigated in this project.

This collaborative project provides the unique opportunity for the successful candidate to receive broad training on preclinical in vivo models and in vitro work as well as cellular and molecular biology and immunology methodologies including confocal microscopy and spectral flow cytometry.

The project will be supervised by two molecular biologists (Beraza and Rushworth) whose work have a strong translational aim. This collaborative project will enable the student to work in different labs at different institutions (Quadram institute and University of East Anglia) and to present their results to wide-ranging audiences in conferences and meetings. The multidisciplinary nature of this project will contribute to build a broad network and will provide the student valuable transferable skills essential for the progression of her/his scientific career.

This project will be carried out at the Quadram institute, which combines research laboratories with clinical facilities, located at the core of the Norwich Research Park.

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2027 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. Full support and advice will be provided by our Professional Internship team.

Shortlisted applicants will be interviewed on the 2nd, 3rd and 4th February 2027 .

Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.

To maximise accessibility and attract students from underrepresented groups to our programme we have introduced bespoke templates for applicant Personal and Research statements which will enable every applicant to fully represent themselves through providing suitable examples and evidence. These forms are on the NRPDTP website and must be used for these sections of the application form.

Entry requirements

At least UK equivalence Bachelors (Honours) 2:1. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).

Start date

1 October 2027

Additional Funding Information

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.

Studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 rate: £21,805, and a Research Training Support Grant of £5,000 pa for each year of the studentship.