裸藻细胞周期的单细胞图谱博士研究员
Phd Studentship: A Single-Cell Atlas of the Euglena Gracilis Cell Cycle
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在构建首个裸藻单细胞图谱，通过对数千个单个细胞进行分析来重建细胞周期中的基因表达波，并探究该程序如何受光照和温度调节。研究将涵盖裸藻培养与成像、单细胞RNA测序工作流程开发以及计算重建细胞周期的全流程。
- 申请条件
- 申请者需为对实验室湿实验和干实验计算都充满热情的好奇心强、具备定量分析能力的毕业生，欢迎生物科学、计算科学或物理科学背景的申请者。
- 待遇
- 提供为期4年的Norwich Research Park Biosciences Doctoral Training Partnership (DTP) 博士奖学金，涵盖直接支付给大学的学费、2026/27学年每年21,805英镑的生活津贴，以及每年5,000英镑的研究培训支持补助金 (RTSG)。
- 申请方式
- 原文未说明具体申请方式与截止地址。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 36 天
- 学科
- 生命科学
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-24
- 详情核验
判定依据（原文摘录）
- 这是一个博士生培养项目
This PhD will change that.
- 工作语言为英语且无本地语言要求
We welcome applicants from the biological, computational or physical sciences.
- 提供奖学金资助
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship.
原文
Euglena gracilis is one of biology's outliers. This single-celled protist diverged from plants and animals over a billion years ago, switches effortlessly between photosynthesis and feeding, and carries a genome stitched together from multiple ancient endosymbionts. It controls its genes in ways that break the textbook rules: trans-splicing, a modified DNA base (base J), and heavy reliance on post-transcriptional control rather than classical promoters.
Despite growing industrial interest in Euglena as a sustainable source of biofuels, bioplastics and nutraceuticals, we still barely understand how it orchestrates gene expression (1) .
This PhD will change that. You will build the first single-cell atlas of Euglena, profiling thousands of individual cells to reconstruct the waves of gene expression that sweep across the cell cycle, and asking how this programme is rewired by light and temperature. Bulk transcriptomics averages over millions of cells and hides this choreography; single-cell approaches pioneered in this project should reveal it. (2, 3)
You will be trained across the full pipeline: culturing and imaging Euglena, developing single-cell RNA-sequencing workflows, and reconstructing the cell cycle computationally. There is real scope to follow your own questions, testing hypotheses about which pathways switch on, when, and why.
The project will be conducted at the Earlham Institute, a world-class BBSRC research centre of excellence in genomics, engineering and computational biology, and AI. You will join a collaborative and supportive research community with access to training and career development opportunities through the Norwich Research Park Biosciences Doctoral Training Partnership.
This project suits a curious, quantitative graduate excited to work at both the bench and the keyboard, and who wants to help crack the biology of one of the most unusual cells on Earth.
We welcome applicants from the biological, computational or physical sciences.
References:
• Ebenezer et al (2022) Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world 11(11):bio059561. doi: 10.1242/bio.059561
• Sebé-Pedrós et al (2025) The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution. 645 877-885. doi: 10.1038/s41586-025-09312-4.
• Dogga SK, et al (2024) A single cell atlas of sexual development in Plasmodium falciparum. Science. 384(6695):eadj4088. doi: 10.1126/science.adj4088
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership PhD DTP studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2026/27 stipend rate: £21,805, and a Research Training Support Grant of £5,000pa for each year of the studentship.