利用先进光学计量学和3D仿体解决深拉曼光谱定量问题的博士研究员
PhD Studentship: Overcoming the Quantification Problem in Deep Raman Spectroscopy using Advanced Optical Metrology and 3D Phantoms
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 该博士项目旨在开发下一代超真实、无动物实验的仿体，以克服深拉曼光谱（DRS）中的“定量问题”，从而实现未来动物研究和多样化医疗保健应用中的定量分析。项目结合了时域漫射光学光谱（TDDOS）、3D打印组织模型和先进的计算机模拟，开发测量光传播并无创定量药物生物分布的工具。
- 申请条件
- 原文未说明具体学位专业背景及其他申请条件要求。
- 待遇
- 提供2026/7年度的学费资助以及每年21,805英镑的生活津贴。
- 申请方式
- 原文未说明具体的申请方式、提交语言及截止具体安排。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- （Europe/London） 剩 40 天
- 学科
- 物理与天文
- 合同类型
- 雇佣合同
- 原文薪资
- GBP 21,805 / 年（税前）
- 税后月薪（估）
- ¥13,700；房租后 ¥5,400
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 原帖发布
- 本站收录
- 内容更新
- 来源
- jobs.ac.uk（英国博士项目及学术招聘） · 最近核对 2026-10-28
- 详情核验
判定依据（原文摘录）
- 这是一个博士项目机会
This PhD project will develop the next generation of hyper realistic animal free phantoms
- 提供学费及生活津贴资助
The studentship will provide funding of fees and a stipend of £21,805 per annum for 2026/7.
原文
Summary:
This PhD project will develop the next generation of hyper realistic animal free phantoms to overcome the "quantification problem" in deep Raman spectroscopy (DRS). This will enable quantitative analysis in future animal studies and varied healthcare applications. By combining time-domain diffuse optical spectroscopy (TDDOS), 3D-printed tissue models, and advanced computer simulations, the project will develop tools to measure light propagation and allow drug biodistribution to be quantified non-invasively.
Motivation: While Raman spectroscopy non-destructively reveals detailed chemical information and is being developed for a range innovative healthcare applications (e.g., theranostic nanomedicines and improved pathology), quantifying these signals in complex 3D samples remains a major barrier. Current methods struggle with inconsistent geometries and varying optical properties. By resolving this quantification problem, we can enable longitudinal biodistribution studies that require fewer animals, directly aligning with the 3Rs principles (replace, reduce, refine) for more ethical research.
Project Aims: The student will develop a pipeline to enable quantitative DRS by achieving three key milestones: Develop and validate a time domain diffuse optical spectroscopy device to precisely quantify optical properties—specifically absorption and reduced scattering within the 1st biological optical window. Utilize 3D printing to create highly realistic, animal-free 3D tissue phantoms that accurately replicate the optical properties of living tissues. Combine high resolution photogrammetry with Monte Carlo modelling to simulate light propagation through complex 3D geometries, moving beyond simplistic layered models. The studentship will provide funding of fees and a stipend of £21,805 per annum for 2026/7.