T细胞免疫学方向博士职位

PhD Position in T Cell Immunology

23.09.2024, Academic staff

The research group of Prof. Marc Schmidt-Supprian at the Institute of Experimental Hematology is seeking a highly motivated PhD student starting from now onwards. The research project focuses on regulatory T (Treg) cells and investigating their context-specific identity and function in B cell-driven autoimmune diseases. This collaborative project is embedded in the Transregional Collaborative Research Centre TRR 355 and is funded for three years.

Project Overview: The candidate will contribute to a collaborative DFG-funded project aimed at understanding the identity and plasticity of regulatory T (Treg) cells, in the context of autoimmunity. The primary objectives include: • to compare central Treg cell identity and function programs between mice and men in normal physiology and autoimmunity in collaboration with project partners • elucidate the transcriptional networks regulated by FoxP3 and c-Rel in Treg cells and screen for novel critical regulators of Treg identity and function in autoimmune contexts • study how context-specific cytokine milieus affect Treg identity as well as plasticity and functionally validate engineered Treg cells with distinct anti- or pro-inflammatory features Key Responsibilities: • Conduct wet lab experiments to generate data describing the context-dependent Treg identity and underlying transcriptional networks. • Collaborate with project partners. • Contribute to the preparation and analysis of data for publication and presentations. The following qualifications will be of advantage but are not stringently required at start: • Strong background in T cell biology/immunology. • Hands-on experience with transgenic mouse models, including breeding and colony management. • Proficiency in preparing and processing lymphoid organs from mice. • Expertise in Flow Cytometry, particularly in multi-color FACS staining and cell population analysis. • Experience/Interest in single cell RNA sequencing experiments. • Excellent proficiency in English, both written and spoken. This is a unique opportunity to contribute to high-impact research in a collaborative and interdisciplinary environment. If you are passionate about T cell immunology and eager to work on a dynamic project, we encourage you to apply. Contact: Prof. Dr. Marc Schmidt-Supprian marc.supprian@tum.de Tel.: 089-4140-4104 Klinikum rechts der Isar Technische Universität München TranslaTUM Einsteinstr. 25 81675 München

The position is suitable for disabled persons. Disabled applicants will be given preference in case of generally equivalent suitability, aptitude and professional performance.

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Kontakt: marc.supprian@tum.de