利用肺泡类器官模型针对衰老肺泡上皮的靶向纳米颗粒研究非临床博士生（固定期限）
AZ funded Non-clinical PhD Studentship (Fixed Term) in selective nanoparticle targeting of senescent alveolar epithelium using an alveolar organoid model
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 本项目旨在开发一个平台，以评估和优化纳米颗粒疗法在肺部衰老调节治疗中的递送，使用人类肺泡类器官作为主要体外模型，重点关注特发性肺纤维化（IPF）中肺泡II型（AT2）细胞的细胞衰老和功能障碍。
- 申请条件
- 申请人应具备或即将获得英国大学的一等或二级上等荣誉学位，或海外大学同等标准的relevant subject学位，以为细胞生物学研究做好准备。职位对符合英国居留要求的英国公民或海外学生（Home费标准）开放，或者能够通过奖学金或资助计划补足国际学生学费额外成本的学生开放，不允许学生通过自筹资金补足学费。
- 待遇
- 提供全额资助，涵盖每年21,500英镑的生活费（Maintenance fees）以及大学学费（University Composition Fee），自2027年10月1日起生效。
- 申请方式
- 申请须通过剑桥大学申请门户网站（https://www.postgraduate.study.cam.ac.uk/courses/directory/cvimpdmsc/apply）提交，申请时及任何关于此空缺的通信中请注明参考编号 SA51375。申请截止日期为2026年12月8日，面试将于2026年12月或2027年1月进行（待确认），鼓励在申请前进行非正式咨询并联系 Dr Dickens（jac72@cam.ac.uk）。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- 原帖未给出
- 学科
- 生命科学
- 合同类型
- 奖学金
- 原文薪资
- GBP 21,500 / 年（税前）
- 估算假设
- 单身、无子女、雇佣合同的粗略估算，以学校 offer 为准；扣除率 18%；汇率日期 2026-10-01
- 本站收录
- 内容更新
- 原帖导师候选（待核验）
- Dr Jennifer Dickens, Dr James Garnett, Dr Catherine Overed-Sayer
- 来源
- The Chancellor, Masters, and Scholars of the University of Cambridge 官方招聘 · 最近核对 2026-10-17
判定依据（原文摘录）
- 这是一项博士培养机会
AZ funded Non-clinical PhD Studentship (Fixed Term) in selective nanoparticle targeting of senescent alveolar epithelium using an alveolar organoid model
- 工作语言为英语（通过海外招生及剑桥大学博士项目常规英语要求体现）
Applications are invited for 4-year PhD studentship based in Cambridge Institute of Medical Research (CIMR), University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge.
- 要求具备相关学士或以上学位（通常英国PhD要求荣誉学位）
Applicants should have or shortly expect to obtain a first or upper second-class degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject which will equip them for cell biology research.
原文
AZ funded Non-clinical PhD Studentship (Fixed Term) in selective nanoparticle targeting of senescent alveolar epithelium using an alveolar organoid model
Applications are invited for 4-year PhD studentship based in Cambridge Institute of Medical Research (CIMR), University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Dr Jennifer Dickens in CIMR and Dr James Garnett and Dr Catherine Overed-Sayer at AstraZeneca and will work have opportunity to work across the two sites.
Project Overview
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal interstitial lung disease (ILD) in which alveolar type 2 (AT2) cell epithelial dysfunction plays a key initiating role. Epithelial senescence is increasingly recognised as playing a role in triggering and perpetuating disease. This project aims to develop a platform in which to assess and optimise the delivery of nanoparticle approaches to senomodulatory therapeutics in the lung.
Senescent-cell targeting nanoparticles will be engineered and loaded with exemplar senomodulatory drugs in collaboration with Prof. Ljiljana Fruk (Department of Chemical Engineering and Biotechnology) and delivered to AT2 cells, using human alveolar organoids as the primary in vitro model. Working with the AstraZeneca team, drug selection will be optimised and an automated screening platform developed to undertake proof-of-concept studies to assess the efficacy and functional effects of nanoparticle-mediated senolytic delivery to AT2 cells.
Candidate
We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently. Applicants should have or shortly expect to obtain a first or upper second-class degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject which will equip them for cell biology research. These positions are open to UK citizens or overseas students who meet the UK residency requirements (home fees) or are able to augment the funds to cover the extra costs associated with international student fees through scholarships or funding schemes. Students will not be allowed to supplement fees via self-funding.
Full details of the University's entrance requirements and scholarships are specified on the following link: https://www.postgraduate.study.cam.ac.uk/
Funding
Full funding covering Maintenance fees at £21,500 per annum and the University Composition Fee is provided for the studentship, with effect from 1 October 2027.
Student Support and Training
As a graduate student at Cambridge, you will have access to a wide range of training opportunities and benefit from close supervision provided by a primary and secondary PhD supervisor as well as a personal mentor.
All students are expected to attend all internal and external seminars held within CIMR. Students will also be encouraged to attend and present at the annual AstraZeneca students symposium.
Students are encouraged to attend the wide variety of lectures and training courses available to them across the Institute and wider University. This includes a centrally run Statistics course and the University Core Skills Training Programme, which includes sessions on Time Management, Presentation and Performance and Scientific Writing. Students at the Institute will be members of the University's Postgraduate School of Life Sciences (PSLS) who offer a wide variety of core skills and professional development training. Visit the Researcher Development page on the PSLS website for more information. In addition, the student can also take advantage of training courses and seminars in therapeutic sciences offered by Cambridge Academy of Therapeutic Sciences.
Application Process
Applications should be made through the University Application Portal https://www.postgraduate.study.cam.ac.uk/courses/directory/cvimpdmsc/apply
This includes details of the required documents for the application.
Informal enquiries are encouraged before applications are made and should be directed to Dr Dickens ( jac72@cam.ac.uk ).
Deadline
The deadline for applications is 8th December 2026 .
Interviews will take place in December 2026 or January 2027, to be confirmed.
Please quote reference SA51375 on your application and in any correspondence about this vacancy.
Diversity and Inclusion
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. We place major emphasis on the importance of teamwork and an enjoyable work environment as a foundation for performing internationally leading research. This will allow the student to acquire cutting edge research methodologies in a supportive environment, where they can focus on undertaking the best possible scientific programme
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.