理解肿瘤起始状态的身份与功能的全额资助博士研究员
Fully-funded PhD studentship: Understanding the identity and function of tumour-initiating states
原帖优先：申请材料、截止时间与资格以原帖和学校官方说明为准。
AI 中文速览
- 研究内容
- 该博士项目将使用体外和体内多种模型，研究前期肿瘤细胞状态之间转换背后的分子和表观遗传机制。具体研究方向将根据学生的兴趣及实验室的新发现进行拓展，可能涉及哺乳动物细胞培养、分子与细胞生物学、遗传扰动、成像、表观遗传与染色质分析以及早期肿瘤发生体内模型。
- 申请条件
- 申请者应持有或预计获得认可大学相关专业的一等或上二等荣誉学位（或同等学历）；对机制生物学以及利用实验方法理解癌症发展基本问题有浓厚兴趣；有实验室研究经验者优先。
- 待遇
- 全额资助的博士生职位（Fully-funded PhD studentship）。
- 申请方式
- 请通过剑桥大学申请者门户网站（University Applicant Portal）申请，并选择2027年10月入学；申请时请注明参考编号SW51026。
由 gemini-2.5-flash-lite 生成，博士岗判定置信度 100%。
岗位信息
- 截止
- 原帖未给出
- 学科
- 生命科学
- 合同类型
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- 内容更新
- 导师
- Prof Masashi Narita
- 来源
- The Chancellor, Masters, and Scholars of the University of Cambridge 官方招聘 · 最近核对 2026-10-10
- 详情核验
判定依据（原文摘录）
- 这是一个博士培养机会
Fully-funded PhD studentship: Understanding the identity and function of tumour-initiating states
- 接受英国及海外学生申请，且应届毕业生或大四本科生可申请
We welcome applications from both UK and overseas students. Applications are invited from recent graduates or final-year undergraduates who hold or expect to gain a First/Upper Second Class degree (or equivalent)
原文
Supervisor: Prof Masashi Narita
Department/location: Cancer Research UK Cambridge Institute
Deadline for application: 16th October 2026
Course start date: 1st October 2027
Project details
For further information about the research group, including their most recent publications, please visit their website at https://www.naritalab.com/
Our laboratory investigates the biology of preneoplastic cell states, with particular interest in how changes in cell functional identity and plasticity are controlled by the epigenome. We are interested in how oncogenic and metabolic signalling reshapes chromatin organisation and gene regulation, how these changes influence cellular fitness and tissue microenvironment, and which states ultimately suppress or promote tumour development.
The PhD project will investigate the molecular and epigenetic mechanisms underlying transitions between preneoplastic cell states using diverse models, both in vitro and in vivo. The precise direction of the project will be developed according to the student's interests and emerging findings in the laboratory. Depending on the specific questions addressed, approaches may include mammalian cell culture, molecular and cell biology, genetic perturbation, imaging, epigenetic and chromatin profiling, and in vivo models of early tumorigenesis. Genomic and single-cell approaches may also be used, supported by collaboration with computational scientists.
References/further reading
• Zhu H, Chan ASL & Narita M. The rise of RAS: how gradual oncogene activation shapes the OIS spectrum. Genes & Development (2025).
• Chan ASL et al. Oncogenic RAS drives a spectrum of cellular states with distinct tumour-propagating potential. Nature (2024).
• Olan I, Ando-Kuri M, Parry AJ et al. HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity. Nature Communications 15, 6891 (2024).
• Cassidy LD et al. Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk. Nature Communications 11, 307 (2020).
• Olan I, Handa T & Narita M. Beyond SAHF: an integrative view of chromatin compartmentalization during senescence. Trends in Cell Biology (2023).
Preferred skills/knowledge
Previous hands-on laboratory research experience is highly desirable. Experience in one or more of the following would be advantageous but is not essential: mammalian cell culture, molecular biology, microscopy, genetic manipulation, chromatin or epigenetic assays, and cancer or ageing model systems.
The successful candidate should have a strong interest in mechanistic biology and in using experimental approaches to understand fundamental questions in cancer development.
Computational or bioinformatics expertise is advantageous but not required. Training and collaborative support will be available to analyse genomic datasets generated during the project.
Eligibility
We welcome applications from both UK and overseas students.
Applications are invited from recent graduates or final-year undergraduates who hold or expect to gain a First/Upper Second Class degree (or equivalent) in a relevant subject from any recognised university worldwide.
Applicants with relevant research experience, gained through Master's study or while working in a laboratory, are strongly encouraged to apply.
How to apply
Please apply via the University Applicant Portal. For further information about the course and to access the Applicant Portal, visit: https://www.postgraduate.study.cam.ac.uk/courses/directory/cvcrpdmsc
You should select to commence study in October 2027.
References
We would appreciate it if you could ask your referees to submit their references as soon as possible upon request, despite the longer University deadline for references. They will receive a request once you have completed the References section of your application.
Please quote reference SW51026 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.